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HAMAP: Clostridium novyi (strain NT) complete proteome
General information

Species:  Clostridium novyi (strain NT)
Species code: CLONN
Taxonomy: Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium (TaxID: 386415) [NEWT/ NCBI]
Description: Clostridium novyi-NT, a Gram +, spore-forming bacteria, is an experimentally developed attenuated strain of pathogenic C.novyi. To do so, the major systemic toxin gene-containing episome has been deleted. It was created to be used as an bacteriolytic anti-tumor agent. An anaerobic bacterium is ideally suited as an anti-tumor agent as the only hypoxic regions within mammals are tumors. Intravenous injection of C.novyi-NT spores in rabbits and mice has produced anti-tumor effects without excessive toxicity. While the spores are very stable, the vegetative form is very sensitive to oxygen.
Properties: Presence of flagella: not known
Human pathogen: No
Interaction: No
Number of membranes: 1
Number of inteins:0
Statistics: Number of CLONN entries in the UniProt Knowledgebase: 2305 (308 in UniProtKB/Swiss-Prot + 1997 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    NT
Genome structure:
Chromosome EMBL accession number CP000382 (circular; 2,547,720 bp) (download entry)
Reference(s):
[1] PubMed=17115055; [ NCBI , EBI , Israel , Japan ]
Bettegowda C., Huang X., Lin J., Cheong I., Kohli M., Szabo S.A., Zhang X., Diaz L.A. Jr., Velculescu V.E., Parmigiani G., Kinzler K.W., Vogelstein B., Zhou S. ;
"The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT.";
Nat. Biotechnol. 24:1573-1580(2006).
Web links:
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid386415%5Borgn%5D
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Cnov_NT
PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p16820_Clo_novyi
 EBI Proteome Analysis page



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