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HAMAP: Dehalococcoides sp. (strain BAV1) complete proteome
General information

Species:  Dehalococcoides sp. (strain BAV1)
Species code: DEHSB
Taxonomy: Bacteria; Chloroflexi; Dehalococcoidetes; Dehalococcoides (TaxID: 216389) [NEWT/ NCBI]
Description: Dehalococcoides sp. (strain BAV1) is an anaerobic bacterium phylogenetically associated with the Chloroflexi. Dehalococcoides sp. (strain BAV1) performs reductive dechlorination and transforms chlorinated ethenes, including vinyl chloride (VC), to innocuous products (i.e., ethene and inorganic chloride. Dehalococcoides sp. (strain BAV1) was isolated from tetrachloroethene-to-ethene-dechlorinating microcosms established with aquifer material collected at the contaminated Bachman Road site in Oscoda, Michigan. Widespread groundwater contamination with chlorinated solvents, particularly chlorinated ethenes, poses environmental and health concerns. All chlorinated ethenes are toxic, and only complete dechlorination results in detoxification. Prior to isolation of strain BAV1, only two bacterial populations were described as capable of dechlorinating tetrachloroethene (PCE) to ethene; Dehalococcoides ethenogenes (strain 195) uses PCE, trichloroethene (TCE) and cis -1,2-dichloroethene (cis-DCE) as metabolic electron acceptors, and Dehalococcoides sp. (strain FL2) grows with TCE, cis-DCE, and trans-1,2-dichloroethene (trans-DCE) . Unfortunately, neither of these two populations grow with VC and the final dechlorination step, VC to ethene, proved to be cometabolic and slow, resulting in VC formation. VC accumulation is particularly troublesome because VC is a human carcinogen. Overcoming the DCE and VC stall is a major obstacle in bioremediation of chlorinated solvent sites. Dehalococcoides sp. (strain BAV1) has been successfully employed in bioremediation at chlorinated solvent sites The genome sequence of strain BAV1 will provide information on the evolution of reductive dehalogenation and the environmentally relevant Dehalococcoides group. The genome will serve as a blueprint for the design of molecular tools to assess and manipulate dechlorination activity at contaminated sites.
Properties: Presence of flagella: No
Human pathogen: No
Interaction: No
Number of membranes: 1
Number of inteins:0
Statistics: Number of DEHSB entries in the UniProt Knowledgebase: 1355 (200 in UniProtKB/Swiss-Prot + 1155 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    BAV1
Genome structure:
Chromosome EMBL accession number CP000688 (circular; 1,341,892 bp) (download entry)
Reference(s):
[1] Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Ritalahti K.M., Loeffler F., Richardson P. ;
"Complete sequence of Dehalococcoides sp. BAV1.";
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
Web links:
Official genome site(s):
http://genome.jgi-psf.org/finished_microbes/deh_b/deh_b.home.html
Other web sites:
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=15770
Genome Atlas: http://www.cbs.dtu.dk/services/gwBrowser/project.php?pid=15770
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Deha_BAV1
PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p15770_Deh_sp
 EBI Proteome Analysis page



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