Home Proteomes Families Hamap-Scan Documents Downloads Links
HAMAP: Escherichia coli O9:H4 (strain HS) complete proteome
General information

Species:  Escherichia coli O9:H4 (strain HS)
Species code: ECOHS
Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia (TaxID: 331112) [NEWT/ NCBI]
Description: Escherichia coli is a Gram-negative straight rod, which either uses peritrichous flagella for mobility or is nonmotile. It is a facultatively anaerobic chemoorganotroph capable of both respiratory and fermentative metabolism. E.coli serves a useful function in the body by suppressing the growth of harmful bacterial species and by synthesising appreciable amounts of vitamins. It is an important component of the biosphere. It colonizes the lower gut of animals and survives when released to the natural environment, allowing widespread dissemination to new hosts. Pathogenic E.coli strains are responsible for infection of the enteric, urinary, pulmonary and nervous systems. Comparison of 20 E.coli/Shigella strains shows the core genome to be about 2000 genes while the pan-genome has over 18,000 genes. There are multiple, striking integration hotspots that are conserved across the genomes, corresponding to regions of abundant and parallel insertions and deletions of genetic material.

E.coli HS is a human commensal isolate that was originally isolated from a laboratory scientist at the Walter Reed Army Institute of Research. In human challenge experiments, strain HS colonized the human gastrointestinal tract with no overt signs of disease. The genome sequence of strain HS represents the genomic baseline for colonization of the human gastrointestinal tract. This isolate is serotype O9, phylogroup A, motile, competent and amenable to genetic manipulation.
Properties: Presence of flagella: Yes
Human pathogen: No
Interaction: Animal commensal in Mammalia
Number of membranes: 2
Number of inteins:0
Statistics: Number of ECOHS entries in the UniProt Knowledgebase: 4308 (841 in UniProtKB/Swiss-Prot + 3467 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    HS
Genome structure:
Chromosome EMBL accession number CP000802 (circular; 4,643,538 bp) (download entry)
Reference(s):
[1] PubMed=18676672; [ NCBI , EBI , Israel , Japan ]
Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F., Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R., Henderson I.R., Sperandio V., Ravel J. ;
"The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates.";
J. Bacteriol. 190:6881-6893(2008).
Web links:
Official genome site(s):
http://gsc.jcvi.org/projects/msc/e_coli_and_shigella/escherichia_coli_hs/index.shtml
Other web sites:
coliBASE: http://xbase.bham.ac.uk/colibase/genome.pl?id=1549
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?db=genomeprj&cmd=Retrieve&dopt=Overview&list_uids=13959
ERIC: http://www.ericbrc.org/portal/eric/ecolihs
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Ecol_HS
 EBI Proteome Analysis page



Tools