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HAMAP: Francisella tularensis subsp. holarctica (strain FTNF002-00 / FTA) complete proteome
General information

Species:  Francisella tularensis subsp. holarctica (strain FTNF002-00 / FTA)
Species code: FRATF
Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales; Francisellaceae; Francisella (TaxID: 458234) [NEWT/ NCBI]
Description: Francisella tularensis is a non-motile, aerobic, rod-shaped Gram-negative bacterium and is the causative agent of tularemia. Tularemia can affect both humans and animals. The subspecies tularensis (Type A) and holarctica (Type B) are the ones most commonly associated with the human disease. Its natural hosts are rabbits, hares, beavers and other rodents, as well as flies and mosquitos. The disease can be transmitted by different ways: through scratches or bites from animals, through consumption of contaminated meat or water or through inhalation of bacteria. The symptoms developed by infected people directly reflect the mode of transmission: pneumonia-like illness for the airborne transmission; throat infection, stomach pain, diarrhea and vomiting for the gastrointestinal transmission; apparition of a sore at the entry point of the bacteria and swelling of the draining lymph nodes for transmission via skin wounds. Tularemia can be treated with antibiotics, but without therapy the mortality rate of respiratory tularemia can be as high as 5-30%. F.tularensis is very infectious and ten cells are sufficient to cause infection in humans. The bacterium can survive for weeks at low temperatures in water, soil or animal carcasses. During World War II, the use of F.tularensis as a biological weapon was studied by Japan, Soviet Union and USA.

Strain FTNF002-00 (formerly known as FTA) was isolated from the first know clinical case of bacteremic F.tularensis pneumonia in France, from an immunocompetent 56-year old male. It shares over 99.9% sequence similarity with previously sequenced F.t.holarctica strains FRATH and FRATO (strains LVS and OSU18 respectively) (adapted from PMID 19756146).
Properties: Presence of flagella: No
Human pathogen: Yes
Interaction: Animal pathogen in Mammalia
Number of membranes: 2
Number of inteins:0
Statistics: Number of FRATF entries in the UniProt Knowledgebase: 1515 (258 in UniProtKB/Swiss-Prot + 1257 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    FTNF002-00 / FTA
Genome structure:
Chromosome EMBL accession number CP000803 (circular; 1,890,909 bp) (download entry)
Reference(s):
[1] PubMed=19756146; [ NCBI , EBI , Israel , Japan ]
Barabote R.D., Xie G., Brettin T.S., Hinrichs S.H., Fey P.D., Jay J.J., Engle J.L., Godbole S.D., Noronha J.M., Scheuermann R.H., Zhou L.W., Lion C., Dempsey M.P. ;
"Complete genome sequence of Francisella tularensis subspecies holarctica FTNF002-00.";
PLoS ONE 4:E7041-E7041(2009).
Web links:
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=20197
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Ftul_FTA
 EBI Proteome Analysis page



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