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HAMAP: Francisella tularensis subsp. mediasiatica (strain FSC147) complete proteome
General information

Species:  Francisella tularensis subsp. mediasiatica (strain FSC147)
Species code: FRATM
Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales; Francisellaceae; Francisella (TaxID: 441952) [NEWT/ NCBI]
Description: Francisella tularensis is a non-motile, aerobic, rod-shaped Gram-negative bacterium and is the causative agent of tularemia. Tularemia can affect both humans and animals. The subspecies tularensis (Type A) and holarctica (Type B) are the ones most commonly associated with the human disease. Its natural hosts are rabbits, hares, beavers and other rodents, as well as flies and mosquitos. The disease can be transmitted by different ways: through scratches or bites from animals, through consumption of contaminated meat or water or through inhalation of bacteria. The symptoms developed by infected people directly reflect the mode of transmission: pneumonia-like illness for the airborne transmission; throat infection, stomach pain, diarrhea and vomiting for the gastrointestinal transmission; apparition of a sore at the entry point of the bacteria and swelling of the draining lymph nodes for transmission via skin wounds. Tularemia can be treated with antibiotics, but without therapy the mortality rate of respiratory tularemia can be as high as 5-30%. F.tularensis is very infectious and ten cells are sufficient to cause infection in humans. The bacterium can survive for weeks at low temperatures in water, soil or animal carcasses. During World War II, the use of F.tularensis as a biological weapon was studied by Japan, Soviet Union and USA.

F.tularensis subspecies mediasiatica rarely causes disease in humans. Strain FSC147 (sometimes called F68) was isolated from a Miday gerbil (Meriones meridianus, also known as mid-day jird and midday gerbil) in 1965 in Kazakhstan.
Properties: Presence of flagella: No
Human pathogen: No
Interaction: No
Number of membranes: 2
Number of inteins:0
Statistics: Number of FRATM entries in the UniProt Knowledgebase: 1388 (238 in UniProtKB/Swiss-Prot + 1150 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    FSC147
Genome structure:
Chromosome EMBL accession number CP000915 (circular; 1,893,886 bp) (download entry)
Reference(s):
[1] PubMed=19521508; [ NCBI , EBI , Israel , Japan ]
Larsson P., Elfsmark D., Svensson K., Wikstroem P., Forsman M., Brettin T., Keim P., Johansson A. ;
"Molecular evolutionary consequences of niche restriction in Francisella tularensis, a facultative intracellular pathogen.";
PLoS Pathog. 5:E1000472-E1000472(2009).
Web links:
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=19571
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Ftul_FSC147
 EBI Proteome Analysis page



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