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HAMAP: Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) complete proteome
General information

Species:  Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Species code: FRATT
Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales; Francisellaceae; Francisella (TaxID: 177416) [NEWT/ NCBI]
Description: Francisella tularensis is a rod-shaped Gram-negative bacterium and is the causative agent of tularemia. Tularemia can affect both humans and animals. The subspecies tularensis (Type A) and holarctica (Type B) are the ones most commonly associated with the human disease. Its natural hosts are rabbits, hares, beavers and other rodents, as well as flies and mosquitos. The disease can be transmitted by different ways: through scratches or bites from animals, through consumption of contaminated meat or water or through inhalation of bacteria. The symptoms developed by infected people directly reflect the mode of transmission: pneumonia-like illness for the airborne transmission; throat infection, stomach pain, diarrhea and vomiting for the gastrointestinal transmission; apparition of a sore at the entry point of the bacteria and swelling of the draining lymph nodes for transmission via skin wounds. Tularemia can be treated with antibiotics, but without therapy the mortality rate of respiratory tularemia can be as high as 5-30%. F.tularensis is very infectious and ten cells are sufficient to cause infection in humans. The bacterium can survive for weeks at low temperatures in water, soil or animal carcasses. During World War II, the use of F.tularensis as a biological weapon was studied by Japan, Soviet Union and USA.

Strain Schu S4 was isolated from a human source in 1941 in the USA.
Properties: Presence of flagella: No
Human pathogen: Yes
Interaction: Animal pathogen in Mammalia
Number of membranes: 2
Number of inteins:0
Statistics: Number of FRATT entries in the UniProt Knowledgebase: 1528 (294 in UniProtKB/Swiss-Prot + 1234 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    SCHU S4 / Schu 4
Genome structure:
Chromosome EMBL accession number AJ749949 (circular; 1,892,775 bp) (download entry)
Reference(s):
[1] PubMed=15640799; [ NCBI , EBI , Israel , Japan ]
Larsson P., Oyston P.C.F., Chain P., Chu M.C., Duffield M., Fuxelius H.-H., Garcia E., Haelltorp G., Johansson D., Isherwood K.E., Karp P.D., Larsson E., Liu Y., Michell S., Prior J., Prior R., Malfatti S., Sjoestedt A., Svensson K., Thompson N., Vergez L., Wagg J.K., Wren B.W., Lindler L.E., Andersson S.G.E., Forsman M., Titball R.W. ;
"The complete genome sequence of Francisella tularensis, the causative agent of tularemia.";
Nat. Genet. 37:153-159(2005).
Web links:
CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Francisella&GLspecies=tularensis&GLstrain=SCHUS4
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid177416%5Borgn%5D
FrantCyc: http://biocyc.org/FRANT/organism-summary?object=FRANT
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Ftul_SCHU4
JVCI CMR: http://cmr.jcvi.org/tigr-scripts/CMR/GenomePage.cgi?database=ntft06
PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p9_Fra_tular
 EBI Proteome Analysis page



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