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Species code:	GRABC
Taxonomy:	Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales; Acetobacteraceae; Granulibacter (TaxID: 391165) [NEWT/ NCBI]
Description:	Acetobacteraceae are alphaproteobacteria including the acetic acid bacteria, which incompletely oxidize carbohydrates and alcohols, leading to production of vinegar among other chemicals. They are found worldwide on plant material. G.bethesdensis is a non-motile Gram-negative rod able to growth on methanol as its sole carbon source, and encodes the enzymes necessary for conversion of alcohols to acetic acid making it both an acetic acid bacterium and a methylotroph. Strain CGDNIH1 was identified in excised lymph nodes from a 39 year old male patient with chronic granulomatous disease (CGD), a rare inherited disease of the phagocyte NADPH oxidase system causing defective production of toxic oxygen metabolites, impaired bacterial and fungal killing, and recurrent life-threatening infections with Staphylococcus aureus, Serratia marcescens, Burkholderia cepacia complex Nocardia and Aspergillus species, and now Granulibacter bethesdensis. This is the first reported case of invasive human disease caused by any of the Acetobacteraceae. It is surrounded by a capsule, which might confer increased resistance.
Properties:	Presence of flagella: No Human pathogen: Yes Interaction: Animal pathogen in Mammalia Number of membranes: 2 Number of inteins:0
Statistics:	Number of GRABC entries in the UniProt Knowledgebase: 2430 (258 in UniProtKB/Swiss-Prot + 2172 in UniProtKB/TrEMBL)

Genome structure:	Chromosome EMBL accession number CP000394 (circular; 2,708,355 bp) (download entry)
Reference(s):	[1] PubMed=17827295; [ NCBI , EBI , Israel , Japan ] Greenberg D.E., Porcella S.F., Zelazny A.M., Virtaneva K., Sturdevant D.E., Kupko J.J. III, Barbian K.D., Babar A., Dorward D.W., Holland S.M. ; "Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis."; J. Bacteriol. 189:8727-8736(2007).
Web links:	Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid391165%5Borgn%5D GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Gbet_CGDNIH1 PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p17111_Gra_bethe  EBI Proteome Analysis page

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