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HAMAP: Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) complete proteome
General information

Species:  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Species code: KLEP7
Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Klebsiella (TaxID: 272620) [NEWT/ NCBI]
Description: Bacteria of the genus Klebsiella are widely distributed in nature, in the soil and in water. They are also part of the normal flora of the intestinal tract, but usually in low numbers compared with E. coli. Klebsiella, especially strains of the species K. pneumonia, are opportunistic pathogens that can cause pneumonia, urinary tract infections, and bacteremia. In recent years there has been an increase in Klebsiella infections, especially in hospitals and due to multiple-antibiotic resistant strains. The most striking difference between most strains of Klebsiella and its close relatives E. coli and Salmonella is that Klebsiella cells have a thick coat of slime or extracellular polysaccharide which is called a "capsule". The capsule protects the cells from dessication, and may also protect them from phagocytosis when they are in an animal host. Surprisingly, many strains of Klebsiella can fix nitrogen, i.e., they can reduce atmospheric nitrogen to ammonia and amino acids.

Klebsiella pneumoniae MGH 78578 (also known as ATCC 700721/SGSC4697) was isolated from the sputum of a 66-year-old ICU patient in 1994. Klebsiella was considered to have a role in his pneumonia. The strain is resistant to many antibiotics, including ampicillin, ticarcillin, trimethoprim-sulfamethoxazole, and gentamicin, but is susceptible to amikacin, ciprofloxacin, and imipenem (adapted from http://genome.wustl.edu/genomes/view/klebsiella_pneumoniae/).
Properties: Presence of flagella: No
Human pathogen: Yes
Interaction: Animal commensal in Mammalia; Animal pathogen in Mammalia
Number of membranes: 2
Number of inteins:0
Statistics: Number of KLEP7 entries in the UniProt Knowledgebase: 5126 (712 in UniProtKB/Swiss-Prot + 4414 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    ATCC 700721 / MGH 78578
Genome structure:
• Chromosome EMBL accession number CP000647 (circular; 5,315,120 bp) (download entry)
• Plasmid pKPN3 EMBL accession number CP000648 (circular; 175,879 bp) (download entry)
• Plasmid pKPN4 EMBL accession number CP000649 (circular; 107,576 bp) (download entry)
• Plasmid pKPN5 EMBL accession number CP000650 (circular; 88,582 bp) (download entry)
• Plasmid pKPN6 EMBL accession number CP000651 (circular; 4,259 bp) (download entry)
• Plasmid pKPN7 EMBL accession number CP000652 (circular; 3,478 bp) (download entry)
Reference(s):
[1] McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K. ;
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
Web links:
Official genome site(s):
http://genome.wustl.edu/genomes/view/klebsiella_pneumoniae/
Other web sites:
coliBASE: http://xbase.bham.ac.uk/colibase/genome.pl?id=1115
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=31
ERIC: http://www.ericbrc.org/portal/eric/klebsiellapneumoniaemgh78578
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Kpne_ATCC700721
PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p31_Kle_pneum
 EBI Proteome Analysis page



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