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HAMAP: Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) complete proteome
General information

Species:  Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Species code: LACAC
Taxonomy: Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus (TaxID: 272621) [NEWT/ NCBI]
Description: Lactobacilli are normal inhabitants of the gastrointestinal tract of man and animals where they are widely considered to exert a number of beneficial roles including immunomodulation, interference with enteric pathogens, and maintenance of a healthy intestinal microflora. Historically, probiotic roles have been ascribed primarily to Lactobacillus acidophilus. The genus Lactobacillus presently comprises more than 50 recognized species of non pathogenic bacteria which in addition to their probiotic effects are useful to human as indispensable agents for the fermentation of foods and feed.

Lactobacillus acidophilus NCFM / NCK56 / N2 is a probiotic strain found in conventional foods like milk, yogurt and dietary supplements. It is commercially available in the United States since the mid-1970s. It has the ability to survive passage through the gastrointestinal tract.
Properties: Presence of flagella: No
Human pathogen: No
Interaction: Animal commensal in Mammalia
Number of membranes: 1
Number of inteins:0
Statistics: Number of LACAC entries in the UniProt Knowledgebase: 1859 (282 in UniProtKB/Swiss-Prot + 1577 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    ATCC 700396 / NCK56 / N2 / NCFM
Genome structure:
Chromosome EMBL accession number CP000033 (circular; 1,993,560 bp) (download entry)
Reference(s):
[1] PubMed=15671160; [ NCBI , EBI , Israel , Japan ]
Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L., McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S., Hamrick A., Cano R., Klaenhammer T.R. ;
"Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM.";
Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005).
Web links:
CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Lactobacillus&GLspecies=acidophilus&GLstrain=NCFM
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid272621%5Borgn%5D
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Laci_NCFM
JVCI CMR: http://cmr.jcvi.org/tigr-scripts/CMR/GenomePage.cgi?database=ntla01
Karyn's Genomes: http://www.ebi.ac.uk/2can/genomes/bacteria/Lactobacillus_acidophilus.html
PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p82_Lac_acido
 EBI Proteome Analysis page



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