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HAMAP: Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1) complete proteome
General information

Species:  Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1)
Species code: METEA
Taxonomy: Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Methylobacteriaceae; Methylobacterium (TaxID: 272630) [NEWT/ NCBI]
Description: Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1) is a pink-pigmented facultative methylotrophs Gram-negative bacterium isolated in 1960 in Oxford, as an airborne contaminant growing on methylamine. It was used as a workhorse to characterize the serine cycle for assimilation of the C1-unit of methylene tetrahydrofolate, a central intermediate in methylotrophic metabolism, and more recently the ethylmalonyl-CoA pathway for glyoxylate regeneration. The common trait of all Methylobacterium species is the ability to grow on one or several reduced one carbon (C1) compounds other than methane, most prominently methanol. M. extorquens contains large sets of insertion elements, many of them strain-specific, suggesting an important potential for genomic plasticity. Most of the genomic determinants associated with methylotrophy are nearly identical in all strains with exceptions that illustrate the metabolic and genomic versatility of Methylobacterium species. M.extorquens (strain ATCC 14718 / DSM 1338 / AM1) possesses a unique methylamine utilization (mau) gene cluster, indicating that strain DSM 5838 / DM4 employs an alternative system for growth with methylamine. The mau clusters represent a chromosomal genomic island and is flanked by mobile elements.(Adaptated from PMID: 19440302).
Properties: Presence of flagella: No
Human pathogen: No
Interaction: No
Number of membranes: 2
Number of inteins:0
Statistics: Number of METEA entries in the UniProt Knowledgebase: 6233 (55 in UniProtKB/Swiss-Prot + 6178 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    ATCC 14718 / DSM 1338 / AM1
Genome structure:
• Chromosome EMBL accession number CP001510 (circular; 5,511,322 bp) (download entry)
• Megaplasmid EMBL accession number CP001511 (circular; 1,261,460 bp) (download entry)
• Plasmid p1META1 EMBL accession number CP001512 (circular; 44,195 bp) (download entry)
• Plasmid p2META1 EMBL accession number CP001513 (circular; 37,858 bp) (download entry)
• Plasmid p3META1 EMBL accession number CP001514 (circular; 24,943 bp) (download entry)
Reference(s):
[1] PubMed=19440302; [ NCBI , EBI , Israel , Japan ]
Vuilleumier S., Chistoserdova L., Lee M.-C., Bringel F., Lajus A., Zhou Y., Gourion B., Barbe V., Chang J., Cruveiller S., Dossat C., Gillett W., Gruffaz C., Haugen E., Hourcade E., Levy R., Mangenot S., Muller E., Nadalig T., Pagni M., Penny C., Peyraud R., Robinson D.G., Roche D., Rouy Z., Saenampechek C., Salvignol G., Vallenet D., Wu Z., Marx C.J., Vorholt J.A., Olson M.V., Kaul R., Weissenbach J., Medigue C., Lidstrom M.E. ;
"Methylobacterium genome sequences: a reference blueprint to investigate microbial metabolism of C1 compounds from natural and industrial sources.";
PLoS ONE 4:E5584-E5584(2009).
Web links:
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=20
Genome Atlas: http://www.cbs.dtu.dk/services/gwBrowser/precalc/project.php?pid=20
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Mext_AM1
 EBI Proteome Analysis page



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