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HAMAP: Methanobrevibacter smithii (strain PS / ATCC 35061 / DSM 861) complete proteome
General information

Species:  Methanobrevibacter smithii (strain PS / ATCC 35061 / DSM 861)
Species code: METS3
Taxonomy: Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales; Methanobacteriaceae; Methanobrevibacter (TaxID: 420247) [NEWT/ NCBI]
Description: Methanobrevibacter smithii (strain ATCC 35061 / DSM 861) is a methanogenic Euryarchaeote which is the dominant archeon in the human gut ecosystem and makes up 10% of all anaerobes in the colons of healthy adults. Studies in gnotobiotic mice indicate that M. smithii affects the specificity and efficiency of bacterial digestion of dietary polysaccharide, thereby influencing host calorie harvest and adiposity. Comparison of the gut microbial communities of genetically obese and lean mice has shown that the former contain an enhanced representation of genes involved in polysaccharide degradation, possess more archaea and exhibit a greater capacity to promote adiposity when transplanted in germ-free recipients. These findings suggest that M. smithii may be a therapeutic target for reducing energy harvest in obese human.
Properties: Presence of flagella: not known
Human pathogen: No
Interaction: Animal commensal in Mammalia
Number of membranes: 1
Number of inteins:0
Statistics: Number of METS3 entries in the UniProt Knowledgebase: 1783 (189 in UniProtKB/Swiss-Prot + 1594 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    PS / ATCC 35061 / DSM 861
Genome structure:
Chromosome EMBL accession number CP000678 (circular; 1,853,160 bp) (download entry)
Reference(s):
[1] PubMed=17563350; [ NCBI , EBI , Israel , Japan ]
Samuel B.S., Hansen E.E., Manchester J.K., Coutinho P.M., Henrissat B., Fulton R., Latreille P., Kim K., Wilson R.K., Gordon J.I. ;
"Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gut.";
Proc. Natl. Acad. Sci. U.S.A. 104:10643-10648(2007).
Web links:
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/genomeprj/18653
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Msmi_ATCC35061
 EBI Proteome Analysis page



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