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HAMAP: Mycobacterium paratuberculosis complete proteome
General information

Species:  Mycobacterium paratuberculosis
Species code: MYCPA
Taxonomy: Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium avium complex (MAC) (TaxID: 1770) [NEWT/ NCBI]
Description: Mycobacterium paratuberculosis strain k10 is the causative agent of Johne's disease in cattle and other ruminants. Strain k10 is a bovine clinical isolate that was isolated from a dairy herd in Wisconsin in the mid-1970s. Johne's disease symptoms include diarrhea, weight loss and decreased milk production. According to a recent study, 21% of the United States dairy herds are infected. Infected animals shed the bacterium in feces and milk, enabling dissemination to other calves, the environment and in retail milk. The genome Mycobacterium paratuberculosis strain k10 consists of a single circular chromosome. It contains more than 3000 genes that have homologs in Mycobacterium tuberculosis. Thirty-nine genes encode predicted proteins that are unique to Mycobacterium paratuberculosis. Roughly 1.5% of the genome is made up of repetitive DNA like insertion sequences, multigene families and duplicated housekeeping genes. The genome contains the complete set of enzymes for several metabolic pathways including glycolysis, the pentose phosphate pathway, the tricarboxylic acid cycle and the glyoxylate cycle. Mycobacterium paratuberculosis is unable to produce the siderophore mycobactin.
Properties: Presence of flagella: No
Human pathogen: Yes
Interaction: Animal pathogen in Mammalia
Number of membranes: 1
Number of inteins:0
Statistics: Number of MYCPA entries in the UniProt Knowledgebase: 4316 (446 in UniProtKB/Swiss-Prot + 3870 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    ATCC BAA-968 / K-10
Genome structure:
Chromosome EMBL accession number AE016958 (circular; 4,829,781 bp) (download entry)
Reference(s):
[1] PubMed=16116077; [ NCBI , EBI , Israel , Japan ]
Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V. ;
"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis.";
Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
Web links:
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid262316%5Borgn%5D
Genome Atlas: http://www.cbs.dtu.dk/services/gwBrowser/precalc/project.php?pid=91
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Mavi_PARATUBERCULOSIS_K10
GOLD: http://genomesonline.org/GOLD_CARDS/Gc00169.html
JVCI CMR: http://cmr.jcvi.org/tigr-scripts/CMR/GenomePage.cgi?database=ntma03
Karyn's Genomes: http://www.ebi.ac.uk/2can/genomes/bacteria/Mycobacterium_avium.html
PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p91_Myc_avium
 EBI Proteome Analysis page



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