HAMAP proteomes
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

General information

Species:  Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Species code: MYCTU
Taxonomy: Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex (TaxID: 83332) [NEWT/ NCBI]
Description: Acid-fast, obligate aerobic, non-motile, rod-shaped bacterium, this is the causative agent of tuberculosis. Tuberculosis is, to this day, according to the WHO, the leading killer of adults, with approximately 2 million deaths annually worldwide. It is estimated that 8 million people are infected each year. A large part of its success as a pathogen is due to its ability to persist in a dormant or latent form for years or even decades, with a concomitant absence of clinical symptoms. This non-replicating persistent form is refractory to most drugs, it may be induced by hypoxia (oxygen depletion) and/or nitric oxide exposure. Up to one-third of the world's population is thought to be latently infected. An additional problem is the emergence of drug resistant strains, mainly because people do not complete their treatment plans or have been incorrectly treated and so have remained infectious.

Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.
Properties: Presence of flagella: No
Human pathogen: Yes
Interaction: Animal pathogen in Mammalia
Number of membranes: 1

Genome(s) sequenced

Strain:    ATCC 25618 / H37Rv
Genome structure:
Chromosome EMBL accession number AL123456 (linear; 4,411,532 bp) (download entry)
Reference(s):
[1] Pubmed=9634230;
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. ;
"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.";
Nature 393:537-544(1998).
Web links:
Official genome site(s):
http://www.sanger.ac.uk/resources/downloads/bacteria/mycobacterium.html
http://tuberculist.epfl.ch/
Other web sites:
BioProject: http://www.ncbi.nlm.nih.gov/bioproject/224
Genome Atlas: http://www.cbs.dtu.dk/services/gwBrowser/precalc/project.php?pid=224
GOLD: http://www.genomesonline.org/cgi-bin/GOLD/GOLDCards.cgi?goldstamp=Gc00015
MtbRvCyc: http://biocyc.org/MTBRV/organism-summary?object=MTBRV
PEDANT: http://pedant.helmholtz-muenchen.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p224_Myc_tuber
Structural genomics; Webtb.org: http://www.webtb.org/Targets/map.php?genome=1

Strain:    ATCC 25618 / H37Rv
Genome structure:
Chromosome EMBL accession number CP003248 (circular; 4,411,709 bp) (download entry)
Reference(s):
[1] Galagan J., Kreiswirth B., Dobos K., Fortune S., Fitzgerald M., Young S.K., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C., Birren B. ;
"The genome sequence of Mycobacterium tuberculosis H37Rv.";
Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
Web links:
BioProject: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA37301
GOLD: http://genomesonline.org/cgi-bin/GOLD/GOLDCards.cgi?goldstamp=Gc02282

Strain:    ATCC 25618 / H37Rv
Genome structure:
Unassembled WGS sequence EMBL accession number JLDD01000000 (unknown; 4,372,083 bp) (download entry)
Reference(s):
[1] Earl A.M., Kreiswirth B., Gomez J., Victor T., Desjardins C., Abeel T., Young S., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., Murphy C., Naylor J., Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C., Birren B. ;
"The genome sequence of Mycobacterium tuberculosis H37Rv.";
Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
Web links:

Strain:    ATCC 27294 / TMC 102 / H37Rv
Genome structure:
Chromosome EMBL accession number CP009480 (circular; 4,396,119 bp) (download entry)
Reference(s):
[1] Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J., Monaco A., King S., Sohrabi A. ;
"Phylogenetic analysis of Mycobacterial species using whole genome sequences.";
Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
Web links:


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