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HAMAP: Mycobacterium tuberculosis complete proteome
General information

Species:  Mycobacterium tuberculosis
Species code: MYCTU
Taxonomy: Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex (TaxID: 1773) [NEWT/ NCBI]
Description: Acid-fast, obligate aerobic, non-motile, rod-shaped bacterium, this is the causative agent of tuberculosis. Tuberculosis is, to this day, according to the WHO, the leading killer of adults, with approximately 2 million deaths annually worldwide. It is estimated that 8 million people are infected each year. A large part of its success as a pathogen is due to its ability to persist in a dormant or latent form for years or even decades, with a concomitant absence of clinical symptoms. This non-replicating persistent form is refractory to most drugs, it may be induced by hypoxia (oxygen depletion) and/or nitric oxide exposure. Up to one-third of the world's population is thought to be latently infected. An additional problem is the emergence of drug resistant strains, mainly because people do not complete their treatment plans or have been incorrectly treated and so have remained infectious.

Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.
Properties: Presence of flagella: No
Human pathogen: Yes
Interaction: Animal pathogen in Mammalia
Number of membranes: 1
Number of inteins: 3 in 3 different sequences
Statistics: Number of MYCTU entries in the UniProt Knowledgebase: 5223 (1917 in UniProtKB/Swiss-Prot + 3306 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    ATCC 25618 / H37Rv
Genome structure:
Chromosome EMBL accession number AL123456 (circular; 4,411,532 bp) (download entry)
Reference(s):
[1] MEDLINE=98295987; PubMed=9634230; [ NCBI , EBI , Israel , Japan ]
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. ;
"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.";
Nature 393:537-544(1998).
Web links:
Official genome site(s):
http://www.sanger.ac.uk/Projects/M_tuberculosis/
Other web sites:
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=224
Genome Atlas: http://www.cbs.dtu.dk/services/gwBrowser/precalc/project.php?pid=224
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Mtub_H37RV
GOLD: http://genomesonline.org/GOLD_CARDS/Gc00015.html
JVCI CMR: http://cmr.jcvi.org/tigr-scripts/CMR/GenomePage.cgi?database=ntmt02
Karyn's Genomes: http://www.ebi.ac.uk/2can/genomes/bacteria/Mycobacterium_tuberculosis.html
MtbRvCyc: http://biocyc.org/MTBRV/organism-summary?object=MTBRV
PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p224_Myc_tuber
Structural genomics: http://www.doe-mbi.ucla.edu/TB/
TubercuList: http://tuberculist.epfl.ch/
 EBI Proteome Analysis page

Strain:    CDC 1551 / Oshkosh
Genome structure:
Chromosome EMBL accession number AE000516 (circular; 4,403,837 bp) (download entry)
Reference(s):
[1] MEDLINE=22206494; PubMed=12218036; [ NCBI , EBI , Israel , Japan ]
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. ;
"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.";
J. Bacteriol. 184:5479-5490(2002).
Web links:
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?db=genomeprj&cmd=Retrieve&dopt=Overview&list_uids=223
Genome Atlas: http://www.cbs.dtu.dk/services/gwBrowser/precalc/project.php?pid=223
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Mtub_CDC1551
GOLD: http://genomesonline.org/GOLD_CARDS/Gc00063.html
JVCI CMR: http://cmr.jcvi.org/tigr-scripts/CMR/GenomePage.cgi?database=gmt
MtbCdcCyc: http://biocyc.org/MTBCDC/organism-summary?object=MTBCDC
PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p223_Myc_tuber
Structural genomics: http://www.doe-mbi.ucla.edu/TB/
 EBI Proteome Analysis page



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