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Species code:	MYCTU
Taxonomy:	Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex (TaxID: 1773) [NEWT/ NCBI]
Description:	Acid-fast, obligate aerobic, non-motile, rod-shaped bacterium, this is the causative agent of tuberculosis. Tuberculosis is, to this day, according to the WHO, the leading killer of adults, with approximately 2 million deaths annually worldwide. It is estimated that 8 million people are infected each year. A large part of its success as a pathogen is due to its ability to persist in a dormant or latent form for years or even decades, with a concomitant absence of clinical symptoms. This non-replicating persistent form is refractory to most drugs, it may be induced by hypoxia (oxygen depletion) and/or nitric oxide exposure. Up to one-third of the world's population is thought to be latently infected. An additional problem is the emergence of drug resistant strains, mainly because people do not complete their treatment plans or have been incorrectly treated and so have remained infectious.
Properties:	Presence of flagella: No Human pathogen: Yes Interaction: Animal pathogen in Mammalia Number of membranes: 1 Number of inteins: 3 in 3 different sequences
Statistics:	Number of MYCTU entries in the UniProt Knowledgebase: 5222 (1899 in UniProtKB/Swiss-Prot + 3323 in UniProtKB/TrEMBL)

Genome structure:	Chromosome EMBL accession number AL123456 (circular; 4,411,532 bp) (download entry)
Reference(s):	[1] MEDLINE=98295987; PubMed=9634230; [ NCBI , EBI , Israel , Japan ] Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. ; "Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence."; Nature 393:537-544(1998).
Web links:	Official genome site(s): http://www.sanger.ac.uk/Projects/M_tuberculosis/ Other web sites: Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=224 Genome Atlas: http://www.cbs.dtu.dk/services/gwBrowser/precalc/project.php?pid=224 GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Mtub_H37RV GOLD: http://genomesonline.org/GOLD_CARDS/Gc00015.html JVCI CMR: http://cmr.jcvi.org/tigr-scripts/CMR/GenomePage.cgi?database=ntmt02 Karyn's Genomes: http://www.ebi.ac.uk/2can/genomes/bacteria/Mycobacterium_tuberculosis.html MtbRvCyc: http://biocyc.org/MTBRV/organism-summary?object=MTBRV PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p224_Myc_tuber Structural genomics: http://www.doe-mbi.ucla.edu/TB/ TubercuList: http://tuberculist.epfl.ch/  EBI Proteome Analysis page

Genome structure:	Chromosome EMBL accession number AE000516 (circular; 4,403,837 bp) (download entry)
Reference(s):	[1] MEDLINE=22206494; PubMed=12218036; [ NCBI , EBI , Israel , Japan ] Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. ; "Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains."; J. Bacteriol. 184:5479-5490(2002).
Web links:	Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?db=genomeprj&cmd=Retrieve&dopt=Overview&list_uids=223 Genome Atlas: http://www.cbs.dtu.dk/services/gwBrowser/precalc/project.php?pid=223 GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Mtub_CDC1551 GOLD: http://genomesonline.org/GOLD_CARDS/Gc00063.html JVCI CMR: http://cmr.jcvi.org/tigr-scripts/CMR/GenomePage.cgi?database=gmt MtbCdcCyc: http://biocyc.org/MTBCDC/organism-summary?object=MTBCDC PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p223_Myc_tuber Structural genomics: http://www.doe-mbi.ucla.edu/TB/  EBI Proteome Analysis page

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