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HAMAP: Neisseria meningitidis serogroup B complete proteome
General information

Species:  Neisseria meningitidis serogroup B
Species code: NEIMB
Taxonomy: Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae; Neisseria (TaxID: 491) [NEWT/ NCBI]
Description: Gram-negative meningococcal bacterium. Neisseria meningitidis colonizes the mucosal surface of the human nose and throat, usually as a commensal bacterium. Up to 15% of the human population are asymptomatic carriers. Sometimes the strains can invade the host, causing life-threatening invasive bacterial infections especially in young infants. They do so by gaining access to the blood and to the cerebrospinal fluid to cause meningitis and septicemia. Thus it is a major cause of morbidity and mortality. The pattern of serogroup B disease is typically hyperendemic or sporadic. Strains of this serogroup are a particular problem because they are a major cause of invasive disease in Europe and United States and there is currently no effective vaccine.
Properties: Presence of flagella: No
Human pathogen: Yes
Interaction: Animal commensal in Mammalia; Animal pathogen in Mammalia
Number of membranes: 2
Number of inteins:0
Statistics: Number of NEIMB entries in the UniProt Knowledgebase: 2001 (572 in UniProtKB/Swiss-Prot + 1429 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    MC58 / Serogroup B
Genome structure:
Chromosome EMBL accession number AE002098 (circular; 2,272,360 bp) (download entry)
Reference(s):
[1] MEDLINE=20175755; PubMed=10710307; [ NCBI , EBI , Israel , Japan ]
Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C., Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L., White O., Fleischmann R.D., Dougherty B.A., Mason T.M., Ciecko A., Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H.M., Qin H., Vamathevan J.J., Gill J., Scarlato V., Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R., Venter J.C. ;
"Complete genome sequence of Neisseria meningitidis serogroup B strain MC58.";
Science 287:1809-1815(2000).
Web links:
CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Neisseria&GLspecies=meningitidis&GLstrain=B_MC58
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid122586%5Borgn%5D
GenoList: http://bioinfo.hku.hk/GenoList/index.pl?database=meningilist
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Nmen_MC58
JVCI CMR: http://cmr.jcvi.org/tigr-scripts/CMR/GenomePage.cgi?database=gnm
Karyn's Genomes: http://www.ebi.ac.uk/2can/genomes/bacteria/Neisseria_meningitidis.html
NMPDR: http://www.nmpdr.org/FIG/wiki/rest.cgi/NmpdrPlugin/SeedViewer?pattern=122586.1;page=SearchResult
PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p251_Nei_menin
 EBI Proteome Analysis page



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