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HAMAP: Pseudomonas aeruginosa (strain LESB58) complete proteome
General information

Species:  Pseudomonas aeruginosa (strain LESB58)
Species code: PSEA8
Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas (TaxID: 557722) [NEWT/ NCBI]
Description: Members of the genus Pseudomonas are characterized by their ability to grow in simple media at the expense of a great variety of organic compounds. They have a strict respiratory metabolism and are motile by one or several polar flagella. They are common inhabitants of soil and water and can also be found on the surfaces of plants and animals. They are are found in nature in a biofilm or in planktonic form. Pseudomonas aeruginosa is an important soil bacterium, with a complex metabolism capable of degrading polycyclic aromatic hydrocarbons, and producing interesting, biologically active secondary metabolites including quinolones, rhamnolipids, lectins, hydrogen cyanide, and phenazines. Production of these products is likely controled by complex regulatory networks making Pseudomonas aeruginosa adaptable both to free-living and pathogenic lifestyles. Human pathogenic strains usually prey on immunocompromised patients.

The widespread assumption that cystic fibrosis (CF) patients acquire only unique strains of P. aeruginosa from the environment was challenged when molecular typing was used to demonstrate the spread of a beta-lactam-resistant isolate, now known as the Liverpool Epidemic Strain (LES), at a children's CF unit in Liverpool, United Kingdom. LES is the most frequent clone isolated from CF patients in England and Wales and has also been reported in Scotland. It can cause superinfection, exhibits enhanced survival on dry surfaces, and is associated with greater patient morbidity than other P. aeruginosa strains. The earliest archived LES isolate, LESB58 was obtained from a Liverpool CF patient in 1988, 8 years prior to the first published study on the LES. It is characterized by early (in the growth curve) overexpression of the cell-density-dependent quorum sensing regulon, including virulence-related secreted factors such as LasA, elastase, and pyocyanin. Furthermore, LESB58 is known to be a biofilm hyperproducer (adapted from PubMed 19047519).
Properties: Presence of flagella: Yes
Human pathogen: Yes
Interaction: Animal pathogen in Mammalia
Number of membranes: 2
Number of inteins:0
Statistics: Number of PSEA8 entries in the UniProt Knowledgebase: 5908 (484 in UniProtKB/Swiss-Prot + 5424 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    LESB58
Genome structure:
Chromosome EMBL accession number FM209186 (circular; 6,601,757 bp) (download entry)
Reference(s):
[1] PubMed=19047519; [ NCBI , EBI , Israel , Japan ]
Winstanley C., Langille M.G.I., Fothergill J.L., Kukavica-Ibrulj I., Paradis-Bleau C., Sanschagrin F., Thomson N.R., Winsor G.L., Quail M.A., Lennard N., Bignell A., Clarke L., Seeger K., Saunders D., Harris D., Parkhill J., Hancock R.E.W., Brinkman F.S.L., Levesque R.C. ;
"Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool epidemic strain of Pseudomonas aeruginosa.";
Genome Res. 19:12-23(2009).
Web links:
Official genome site(s):
http://www.sanger.ac.uk/Projects/P_aeruginosa/
Other web sites:
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=31101
Genome Atlas: http://www.cbs.dtu.dk/services/gwBrowser/project.php?pid=31101
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Paer_LESB58
 EBI Proteome Analysis page



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