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Species code:	RENSM
Taxonomy:	Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Micrococcineae; Micrococcaceae; Renibacterium (TaxID: 288705) [NEWT/ NCBI]
Description:	Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / IFO 15589) is a Gram-positive, rod-shaped bacterium that causes the bacterial kidney disease (BKD) in salmonids. BKD is the most difficult bacterial disease of farmed fish to control, in part because of its dual mode of transmission. R. salmoninarum is transmitted vertically from parent fish to progeny in association with the eggs, as well as horizontally from fish to fish. Additionally treatment is not really effective as the bacterium hides insides the fish cells, such as the white blood cells, which drugs and the immune system penetrate poorly. It is for this same reason that an effective vaccine has not been developed. The only solution to the problem is disinfection of roe, disposal of infected fish and disinfection of the whole fish farming environment. The disease develops gradually with slowly growing mortality. The disease is chronic in nature, and mortality occurs most often in 6- to 12-month-old juvenile salmonids and prespawning adults. It has been detected in fish in freshwater as well as saline waters, in all age groups in wild stocks and in fish culture facilities. Different species of salmonids have different level of susceptibility. It is the greatest cause of infectious disease related mortality in restoration and conservation programs for several endangered species (adapted from PMID18723615).
Properties:	Presence of flagella: No Human pathogen: No Interaction: Animal pathogen in Fish Number of membranes: 1 Number of inteins:0
Statistics:	Number of RENSM entries in the UniProt Knowledgebase: 3421 (156 in UniProtKB/Swiss-Prot + 3265 in UniProtKB/TrEMBL)

Genome structure:	Chromosome EMBL accession number CP000910 (circular; 3,155,250 bp) (download entry)
Reference(s):	[1] PubMed=18723615; [ NCBI , EBI , Israel , Japan ] Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S. ; "Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."; J. Bacteriol. 190:6970-6982(2008).
Web links:	Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid288705%5Borgn%5D GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Rsal_ATCC33209 GOLD: http://genomesonline.org/cgi-bin/GOLD/bin/GOLDCards.cgi?goldstamp=Gc00698  EBI Proteome Analysis page

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