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HAMAP: Rickettsia bellii (strain RML369-C) complete proteome
General information

Species:  Rickettsia bellii (strain RML369-C)
Species code: RICBR
Taxonomy: Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; Rickettsiaceae; Rickettsieae; Rickettsia (TaxID: 336407) [NEWT/ NCBI]
Description: Rickettsia bellii (strain RML369-C) was isolated in embryonated chicken eggs from a triturated pool of unfed adult Dermacentor variabilis ticks collected from vegetation near Fayetteville, Arkansas, in June of 1966. R.bellii is the most common rickettsia found in ticks in America, in which it is transovarially transmitted. It has been found in various hard ticks including species of Dermacentor and Amblyomma. It is also the sole rickettsia found in both soft and hard ticks, therefore exhibiting the largest arthropod host range among known rickettsiae. Its genome is made up of a single circular chromosome. Several transposase genes of R.bellii are split into two ORFs. It possesses genes for toxin antitoxin systems (8 for toxin and 9 for antitoxin) as well as 10 paralogous genes for spoT. It has a tra gene cluster predicted to encode a type IV secretion system (T4SS) for conjugal DNA transfer. The tra gene cluster is composed of a "F-like region" and a "Ti-like region". This tra gene cluster thus encodes the most complete DNA transfer machinery found so far in Rickettsia. Transmission electron microscopy has revealed the presence of pili on the surface of R.bellii. They are long and flexible and connect bacteria with each other. They are likely to be involved in the early stages of conjugation. In guinea pigs and rabbits intradermal injection of 50 R.bellii caused slight inflammatory reactions, and inoculation of 50,000 R.bellii induced a black necrotic eschar.
Properties: Presence of flagella: No
Human pathogen: not known
Interaction: No
Number of membranes: 2
Number of inteins:0
Statistics: Number of RICBR entries in the UniProt Knowledgebase: 1400 (439 in UniProtKB/Swiss-Prot + 961 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    RML369-C
Genome structure:
Chromosome EMBL accession number CP000087 (circular; 1,522,076 bp) (download entry)
Reference(s):
[1] PubMed=16703114; [ NCBI , EBI , Israel , Japan ]
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D. ;
"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens.";
PLoS Genet. 2:733-744(2006).
Web links:
CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Rickettsia&GLspecies=bellii&GLsupStrain=RML369-C
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid336407%5Borgn%5D
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Rbel_RML369C
PATRIC: http://patric.vbi.vt.edu/genome/overview.php?genomeId=236
PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p13996_Ric_belli
 EBI Proteome Analysis page
 UniProtKB/Swiss-Prot document



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