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HAMAP: Saccharopolyspora erythraea (strain NRRL 23338) complete proteome
General information

Species:  Saccharopolyspora erythraea (strain NRRL 23338)
Species code: SACEN
Taxonomy: Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Pseudonocardineae; Pseudonocardiaceae; Saccharopolyspora (TaxID: 405948) [NEWT/ NCBI]
Description: Saccharopolyspora erythraea (Strain ATCC 11635 / DSM 40517 / NRRL 2338) is an obligate aerobic bacterium phylogenetically associated with the Actinobacteria. This soil bacterium produces the industrially important antibiotic erythromycin A. The genome of S. erythraea is apparently circular rather than linear. This is the white, less-pigmented form, which produced substantially more erythromycin than the red form. Erythromycin is a clinically important and potent macrolide antibiotic. It is used to treat infections caused by several prokaryotic pathogens such as Streptococcus, Staphylococcus, Mycoplasma, Ureaplasma, Chlamydia and Legionella. Production of this antibiotic is lower than others in the same class, such as penicillin or cephalosporin, which has led to the development of a genetic system to attempt to enhance the production of erythromycin.
Properties: Presence of flagella: No
Human pathogen: No
Interaction: No
Number of membranes: 1
Number of inteins:0
Statistics: Number of SACEN entries in the UniProt Knowledgebase: 7154 (262 in UniProtKB/Swiss-Prot + 6892 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    NRRL 23338
Genome structure:
Chromosome EMBL accession number AM420293 (circular; 8,212,805 bp) (download entry)
Reference(s):
[1] PubMed=17369815; [ NCBI , EBI , Israel , Japan ]
Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S., Haydock S.F., Leadlay P.F. ;
"Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.";
Nat. Biotechnol. 25:447-453(2007).
Web links:
Official genome site(s):
http://131.111.43.95/gnmweb/index.html
Other web sites:
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid405948%5Borgn%5D
Genome Atlas: http://www.cbs.dtu.dk/services/gwBrowser/project.php?pid=18489
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Sery_NRRL2338
PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p18489_Sac_eryth
 EBI Proteome Analysis page



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