HAMAP: Salmonella heidelberg (strain SL476) complete proteome

General information

Species:  Salmonella heidelberg (strain SL476)
Species code: SALHS
Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Salmonella (TaxID: 454169) [NEWT/ NCBI]
Description: Salmonella species belong to the group of Enterobactericiae. These bacteria were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The majority of the components of these bacteria are identical, and at the DNA level, they are between 95% and 99% identical. Many Salmonella enterica are involved in causing diseases of the intestine (enteric means pertaining to the intestine). The nontyphoidal Salmonella are the leading cause of bacterial food borne illness in humans, making these pathogens an immediate biomedical, public health, and biodefense concern. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria, which then leads to systemic spread.

In recent years, Salmonella heidelberg (strain SL476) has been the third or fourth most common Salmonella serotype causing disease in the U.S., estimated at 84,000 cases of illness annually. Epidemic outbreaks of S. heidelberg present a significant economic burden to healthcare systems in the United States and elsewhere, although studies have failed to elucidate the genetic factors of S. heidelberg that make it a particularly virulent serovar. The recent rise in S. heidelberg in the United States is accompanied by a concomitant increase in antimicrobial resistance. MDR strain SL476 (NARMS alternate designations: CVMN418, CVM30485) and antibiotic susceptible strain SL486 were chosen from this serotype.
Properties: Presence of flagella: Yes
Human pathogen: Yes
Interaction: No
Number of membranes: 2
Statistics: Number of SALHS entries in UniProtKB: 4757 (710 in UniProtKB/Swiss-Prot + 4047 in UniProtKB/TrEMBL)

Genome(s) sequenced

Strain:    SL476
Genome structure:
• Chromosome EMBL accession number CP001120 (circular; 4,888,768 bp) (download entry)
• Plasmid pSL476_91 EMBL accession number CP001118 (circular; 91,374 bp) (download entry)
• Plasmid pSL476_3 EMBL accession number CP001119 (circular; 3,373 bp) (download entry)
Reference(s):
[1] Ravel J., Fricke W.F., White D., McDermott P., Mammel M., Rosovitz M., Leclerc J., Cebula T., Sebastian Y. ;
"Complete genome of Salmonella heidelberg strain SL476.";
Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
Web links:
Official genome site(s):
http://msc.jcvi.org/salmonella/salmonella_enterica_subsp__enterica_serovar_heidelberg_str__cvm30485/index.shtml
Other web sites:
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=20045
Genome Atlas: http://www.cbs.dtu.dk/services/GenomeAtlas-3.0/?action=acct&pid=20045
GIB (DDBJ): http://gtps.ddbj.nig.ac.jp/single/index.php?spid=Sent_SL476
PEDANT: http://pedant.helmholtz-muenchen.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p20045_Sal_enter


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