 |
|
|||||||
| HAMAP: Salmonella paratyphi A (strain AKU_12601) complete proteome |
General information
Species: Salmonella paratyphi A (strain AKU_12601)
| Species code: | SALPK |
| Taxonomy: | Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Salmonella (TaxID: 554290) [NEWT/ NCBI] |
| Description: | Salmonella species belong to the group of Enterobactericiae. These bacteria were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The majority of the components of these bacteria are identical, and at the DNA level, they are between 95% and 99% identical. Many Salmonella enterica are involved in causing diseases of the intestine (enteric means pertaining to the intestine). The nontyphoidal Salmonella are the leading cause of bacterial food borne illness in humans, making these pathogens an immediate biomedical, public health, and biodefense concern. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria, which then leads to systemic spread Salmonella paratyphi A (strain AKU_12601) is a human-adapted bacterial pathogen that causes related systemic diseases called enteric fever. It was isolated from a child with paratyphoid fever in Karachi, (Pakistan) in 2002. While endemic enteric fever has been eliminated from most developed nations by improved sanitation, enteric fever is still a significant health threat in Southeast Asia, the Indian subcontinent, Africa and to a lesser extent in South America. S. paratyphi A is generally regarded as a less common cause of enteric fever than S. typhi but this serovar causes approximately 25% of enteric fever cases in some regions. Unlike S. typhi, S. paratyphi A isolates have been predominantly susceptible to antibiotics. However, in recent 22 years there have been increasing incidents of multiple drug resistance (MDR) S. paratyphi A, particularly in Asia. A recent study in Nepal found MDR was more common among S. paratyphi A than S. typhi isolates. The situation is perhaps most extreme in China, where paratyphoid fever is now more common than typhoid fever in some regions and is largely drug resistant. Additionally, many S. paratyphi A isolates are resistant to quinolones and so, as with S. typhi-associated typhoid, the infection responds poorly to treatment with the fluoroquinolones. |
| Properties: |
Presence of flagella:
Yes Human pathogen: Yes Interaction: Animal pathogen in Mammalia Number of membranes: 2 Number of inteins:0 |
| Statistics: | Number of SALPK entries in the UniProt Knowledgebase: 4275 (714 in UniProtKB/Swiss-Prot + 3561 in UniProtKB/TrEMBL) |
Genome(s) sequenced
Strain: AKU_12601
| Genome structure: |
|
||||||||
| Reference(s): |
|
||||||||
| Web links: |
|
||||||||
Tools
- Perform a BLAST search against all proteins from this proteome
- Download all UniProt Knowledgebase entries of this proteome
- Retrieve set of characterized or identified proteins for this proteome
- Retrieve set of proteins with 3D structure for this proteome