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HAMAP: Shigella boydii serotype 4 (strain Sb227) complete proteome
General information

Species:  Shigella boydii serotype 4 (strain Sb227)
Species code: SHIBS
Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Shigella (TaxID: 300268) [NEWT/ NCBI]
Description: Shigella is a Gram-negative, non-sporulating, facultative anaerobe bacterium that causes dysentery or shigellosis in man. Shigella are highly invasive in the colon and the rectum, and are able to proliferate in the host cell cytoplasm, triggering an inflammatory reaction. Shigella was recognized as the etiologic agent for bacillary dysentery in the 1890's, and adopted as a genus in the 1950's and subgrouped into four species. However, a recent genetic study argues that Shigella emerged from multiple independent origins of E.coli 35'000-270'000 years ago and may not constitute a genus. S.boydii is mainly epidemic to the Indian subcontinent. Comparison of 20 E.coli/Shigella strains shows the core genome to be about 2000 genes while the pan-genome has over 18,000 genes. There are multiple, striking integration hotspots that are conserved across the genomes, corresponding to regions of abundant and parallel insertions and deletions of genetic material.

Shigella boydii (strain Sb227) was isolated from epidemics in China during the 1950's. Strain Sb227 harbors one chromosome and one plasmid. The IS-element IS1 is predominant in Sb227. A newly identified ISSbo6 element has be found mainly in the chromosome. Most of its copies are located within the SHI-1, SHI-2 and ipaH pathogenicity islands. It also contains the previously reported SHI-3. It has lost flagellar function due to muations in several different genes.
Properties: Presence of flagella: No
Human pathogen: Yes
Interaction: Animal pathogen in Mammalia
Number of membranes: 2
Number of inteins:0
Statistics: Number of SHIBS entries in the UniProt Knowledgebase: 3938 (829 in UniProtKB/Swiss-Prot + 3109 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    Sb227
Genome structure:
• Chromosome EMBL accession number CP000036 (circular; 4,519,823 bp) (download entry)
• Plasmid pSB4_227 EMBL accession number CP000037 (circular; 126,697 bp) (download entry)
Reference(s):
[1] PubMed=16275786; [ NCBI , EBI , Israel , Japan ]
Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X., Wang J., Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S., Nie H., Peng J., Xu J., Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y., Qiang B., Hou Y., Yu J., Jin Q. ;
"Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.";
Nucleic Acids Res. 33:6445-6458(2005).
Web links:
Official genome site(s):
http://www.mgc.ac.cn/ShiBASE/circular_Sb227.htm
Other web sites:
CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Shigella&GLspecies=boydii&GLstrain=Sb227
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid300268%5Borgn%5D
ERIC: http://www.ericbrc.org/portal/eric/shigellaboydii227
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Sboy_SB227
PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p13146_Shi_boydi
 EBI Proteome Analysis page



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