Home Proteomes Families Hamap-Scan Documents Downloads Links
HAMAP: Shigella dysenteriae serotype 1 (strain Sd197) complete proteome
General information

Species:  Shigella dysenteriae serotype 1 (strain Sd197)
Species code: SHIDS
Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Shigella (TaxID: 300267) [NEWT/ NCBI]
Description: Shigella is a Gram-negative, non-sporulating, facultative anaerobe bacterium that causes dysentery or shigellosis in man. Shigella are highly invasive in the colon and the rectum, and are able to proliferate in the host cell cytoplasm, triggering an inflammatory reaction. Shigella was recognized as the etiologic agent for bacillary dysentery in the 1890's, and adopted as a genus in the 1950's and subgrouped into four species. However, a recent genetic study argues that Shigella emerged from multiple independent origins of E.coli 35'000-270'000 years ago and may not constitute a genus. Comparison of 20 E.coli/Shigella strains shows the core genome to be about 2000 genes while the pan-genome has over 18,000 genes. There are multiple, striking integration hotspots that are conserved across the genomes, corresponding to regions of abundant and parallel insertions and deletions of genetic material.

Shigella dysenteriae causes deadly epidemics in many of the poorer countries of the world. Shigella dysenteriae (strain Sd197) was isolated from epidemics in China during the 1950's. It harbors one chromosome and one plasmid. The IS-element IS1N is copiously present in the chromosome. The SHI-1, SHI-2 and SHI-3 pathogenicity islands are absent from Sd197. It has lost flagellar function due to muations in several different genes.
Properties: Presence of flagella: No
Human pathogen: Yes
Interaction: Animal pathogen in Mammalia
Number of membranes: 2
Number of inteins:0
Statistics: Number of SHIDS entries in the UniProt Knowledgebase: 3891 (817 in UniProtKB/Swiss-Prot + 3074 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    Sd197
Genome structure:
• Chromosome EMBL accession number CP000034 (circular; 4,369,232 bp) (download entry)
• Plasmid pSD1_197 EMBL accession number CP000035 (circular; 182,726 bp) (download entry)
Reference(s):
[1] PubMed=16275786; [ NCBI , EBI , Israel , Japan ]
Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X., Wang J., Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S., Nie H., Peng J., Xu J., Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y., Qiang B., Hou Y., Yu J., Jin Q. ;
"Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.";
Nucleic Acids Res. 33:6445-6458(2005).
Web links:
Official genome site(s):
http://www.mgc.ac.cn/ShiBASE/circular_Sd197.htm
Other web sites:
CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Shigella&GLspecies=dysenteriae&GLsupStrain=Sd197
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid300267%5Borgn%5D
ERIC: http://www.ericbrc.org/portal/eric/shigelladysenteriae197
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Sdys_SD197
PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p13145_Shi_dysen
 EBI Proteome Analysis page



Tools