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HAMAP: Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) complete proteome
General information

Species:  Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Species code: STAS1
Taxonomy: Bacteria; Firmicutes; Bacillales; Staphylococcus (TaxID: 342451) [NEWT/ NCBI]
Description: Staphylococcus saprophyticus is the frequent cause of uncomplicated urinary tract infections (UTI) in young and middle-aged women. S.saprophyticus (strain ATCC 15305 / DSM 20229) was isolated from a human urine specimen. It harbors 2 plasmids pSSP1 and pSSP2. Its genome contains various mobile genetic elements including one prophage remnant, two IS431 elements, nine putative transposases, two staphylococcal cassettes (SCC), one of which carries a capsular polysaccharide synthesis locus, and one genomic island. The genomic island carries resistance determinants against streptomycin and fosfomycin instead of virulence factors. Genes involved in transport and regulation are abundant whereas there are fewer genes implicated in virulence than in S.aureus and S.epidermidis. Virulence factors such as coagulase, hemolysins, enterotoxins, extracellular matrix-binding proteins are absent. There is a unique cell wall-anchored protein involved in the adherence to uroepithelial cells. There are numerous transporter systems that evolved through paralog expansion. Unlike most uropathogenic bacteria, it has neither siderophores nor alpha-keto acid siderophore-producing systems. However, it possesses homologs of the NRAMP family. It lacks the potassium-importing ATPase. The agr locus, involved in regulation of virulence genes, is suprisingly well conserved conserved despite the absence of typical virulence factors.
Properties: Presence of flagella: No
Human pathogen: Yes
Interaction: Animal pathogen in Mammalia
Number of membranes: 1
Number of inteins:0
Statistics: Number of STAS1 entries in the UniProt Knowledgebase: 2404 (602 in UniProtKB/Swiss-Prot + 1802 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    ATCC 15305 / DSM 20229
Genome structure:
• Chromosome EMBL accession number AP008934 (circular; 2,516,575 bp) (download entry)
• Plasmid pSSP1 EMBL accession number AP008935 (circular; 38,454 bp) (download entry)
• Plasmid pSSP2 EMBL accession number AP008936 (circular; 22,870 bp) (download entry)
Reference(s):
[1] PubMed=16135568; [ NCBI , EBI , Israel , Japan ]
Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T. ;
"Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection.";
Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
Web links:
CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Staphylococcus&GLspecies=saprophyticus&GLstrain=saprophyticus
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid342451%5Borgn%5D
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Ssap_SAPROPHYTICUS
JVCI CMR: http://cmr.jcvi.org/tigr-scripts/CMR/GenomePage.cgi?database=ntss03
NMPDR: http://www.nmpdr.org/FIG/wiki/rest.cgi/NmpdrPlugin/SeedViewer?pattern=342451.4;page=SearchResult
PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p15596_Sta_sapro
 EBI Proteome Analysis page



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