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HAMAP: Streptococcus pyogenes serotype M12 (strain MGAS2096) complete proteome
General information

Species:  Streptococcus pyogenes serotype M12 (strain MGAS2096)
Species code: STRPB
Taxonomy: Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus (TaxID: 370553) [NEWT/ NCBI]
Description: The group A streptococci (GAS, Streptococcus pyogenes) are gram-positive, nonmotile, nonsporeforming coccus that occur in chains or in pairs of cells. Individual cells are round-to-ovoid cocci, 0.6-1.0 micrometer in diameter. They are catalase-negative aerotolerant anaerobe (facultative anaerobe) which require enriched medium containing blood in order to grow. Their capsule is composed of hyaluronic acid. GAS are important human pathogens which can cause a variety of diseases, ranging from mild infections to very severe invasive diseases. The M protein is a highly polymorphic cell-surface molecule that is antiphagocytic and forms the basis of a scheme commonly used to classify GAS strains. Serotype M3 strains cause a higher rate of lethal infections than strains of other M types. In addition, serotype M3 and other GAS strains can undergo rapid shifts in disease frequency and display epidemic behaviour. This is a serotype M12 strain of S.pyogenes.
Properties: Presence of flagella: No
Human pathogen: Yes
Interaction: Animal pathogen in Mammalia
Number of membranes: 1
Number of inteins:0
Statistics: Number of STRPB entries in the UniProt Knowledgebase: 1885 (268 in UniProtKB/Swiss-Prot + 1617 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    MGAS2096
Genome structure:
Chromosome EMBL accession number CP000261 (circular; 1,860,355 bp) (download entry)
Reference(s):
[1] PubMed=16636287; [ NCBI , EBI , Israel , Japan ]
Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R., Musser J.M. ;
"Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus.";
Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006).
Web links:
CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?KLSO=ASC&KLSK=ORGANISMSORT&kingdom=Bacteria&GLgenus=Streptococcus&GLSHWPLA=on&GLSHWMERG=on&GLspecies=pyogenes&GLsupStrain=MGAS2096
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid370553%5Borgn%5D
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Spyo_MGAS2096
NMPDR: http://www.nmpdr.org/FIG/wiki/rest.cgi/NmpdrPlugin/SeedViewer?pattern=370553.3;page=SearchResult
PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p16365_Str_pyoge
 EBI Proteome Analysis page



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