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HAMAP: Thermococcus onnurineus (strain NA1) complete proteome
General information

Species:  Thermococcus onnurineus (strain NA1)
Species code: THEON
Taxonomy: Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Thermococcus (TaxID: 523850) [NEWT/ NCBI]
Description: Thermococcus onnurineus (strain NA1) is a sulfur-reducing hyperthermophilic carboxydotrophic archaeum isolated from a deep-sea hydrothermal vent sediment (at a depth of 1650 meters) in the PACMANUS field of the East Manus Basin. T. onnurineus requires elemental sulfur as a terminal electron acceptor for heterotrophic growth on peptides or an amino acid mixture and exhibits optimum growth at 80 degrees Celsius and pH 8.5. It has a single circular chromosome, which possesses a unique gene cluster CODH (Carbon monoxide dehydrogenase). This genome encodes unique proteins involved in carboxydotrophy to generate energy by oxidation of CO to CO2 (carboxydotrophy), thereby providing a mechanistic basis for growth with CO as a substrate. This lithotrophic feature in combination with carbon fixation via RuBisCO (ribulose 1,5-bisphosphate carboxylase/oxygenase) introduces a new strategy with a complementing energy supply for T. onnurineus potentially allowing it to cope with nutrient stress in the surrounding of hydrothermal vents, providing the first genomic evidence for the carboxydotrophy in Thermococcus. The novel combination of carbon fixation and carboxydotrophy suggests that when heterotrophic substrates are not available and CO2 formed by catabolism is limited, the CO2 yield from CO oxidation would be a suitable substrate for the RuBisCO enzyme.
Properties: Presence of flagella: No
Human pathogen: No
Interaction: No
Number of membranes: 1
Number of inteins: 3 in 3 different sequences
Statistics: Number of THEON entries in the UniProt Knowledgebase: 1976 (189 in UniProtKB/Swiss-Prot + 1787 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    NA1
Genome structure:
Chromosome EMBL accession number CP000855 (linear; 1,847,607 bp) (download entry)
Reference(s):
[1] PubMed=18790866; [ NCBI , EBI , Israel , Japan ]
Lee H.S., Kang S.G., Bae S.S., Lim J.K., Cho Y., Kim Y.J., Jeon J.H., Cha S.-S., Kwon K.K., Kim H.-T., Park C.-J., Lee H.-W., Kim S.I., Chun J., Colwell R.R., Kim S.-J., Lee J.-H. ;
"The complete genome sequence of Thermococcus onnurineus NA1 reveals a mixed heterotrophic and carboxydotrophic metabolism.";
J. Bacteriol. 190:7491-7499(2008).
Web links:
Official genome site(s):
http://www.moeri.re.kr/eng/study/post02.aspx
Other web sites:
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=20773
Genome Atlas: http://www.cbs.dtu.dk/services/gwBrowser/project.php?pid=20773
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Tonn_NA1
 EBI Proteome Analysis page



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