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HAMAP: Wolbachia sp. subsp. Brugia malayi (strain TRS) complete proteome
General information

Species:  Wolbachia sp. subsp. Brugia malayi (strain TRS)
Species code: WOLTR
Taxonomy: Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; Anaplasmataceae; Wolbachieae; Wolbachia (TaxID: 292805) [NEWT/ NCBI]
Description: Wolbachia strain TRS is the obligate endosymbiont of the nematode Brugia malayi and is required for fertility and survival of the worm. Brugia malayi as well as Wuchereria bancrofti cause lymphatic filariasis, a disease that affects 120 million people, a third of whom show disfigurement. In nematodes, Wolbachia is located in the lateral chords in both sexes and are also localized in oocytes. The bacterium seems to be present in 100% of individuals within a population, when a species contains them. As they appear to be essential to the worm survival, they represent potential therapeutic targets for filariasis control. Some antibiotics show inhibitory effects on parasitic nematode development and fertility. No antibiotic effects are observed in nematodes that do not harbor Wolbachia. Wolbachia play a role in the host immunological response to filarial parasite invasion. Infection by filarial parasites results in the production of antibodies directed toward parasite- and Wolbachia-specific antigens.
Properties: Presence of flagella: No
Human pathogen: No
Interaction: Animal endosymbiont in nematode Brugia malayi (obligate endosymbiont)
Number of membranes: not known
Number of inteins:0
Statistics: Number of WOLTR entries in the UniProt Knowledgebase: 805 (194 in UniProtKB/Swiss-Prot + 611 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    TRS
Genome structure:
Chromosome EMBL accession number AE017321 (circular; 1,080,084 bp) (download entry)
Reference(s):
[1] PubMed=15780005; [ NCBI , EBI , Israel , Japan ]
Foster J., Ganatra M., Kamal I., Ware J., Makarova K., Ivanova N., Bhattacharyya A., Kapatral V., Kumar S., Posfai J., Vincze T., Ingram J., Moran L., Lapidus A., Omelchenko M., Kyrpides N., Ghedin E., Wang S., Goltsman E., Joukov V., Ostrovskaya O., Tsukerman K., Mazur M., Comb D., Koonin E., Slatko B. ;
"The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode.";
PLoS Biol. 3:599-614(2005).
Web links:
CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Wolbachia&GLspecies=endosymbiont&GLstrain=TRS
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid292805%5Borgn%5D
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Wend_TRS
JVCI CMR: http://cmr.jcvi.org/tigr-scripts/CMR/GenomePage.cgi?database=gbw
Karyn's Genomes: http://www.ebi.ac.uk/2can/genomes/bacteria/Wolbachia2.html
PEDANT: http://pedant.gsf.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_p12475_Wol_endos
 EBI Proteome Analysis page



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