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HAMAP: Yersinia pestis bv. Antiqua (strain Angola) complete proteome
General information

Species:  Yersinia pestis bv. Antiqua (strain Angola)
Species code: YERPG
Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Yersinia (TaxID: 349746) [NEWT/ NCBI]
Description: Gram-negative straight rods, sometimes approaching a spherical shape. Y.pestis is always nonmotile. It is the causative agent of plague which is primarily a disease of wild rodents. Y.pestis is transmitted among wild rodents by fleas, in which the bacteria multiply and block the esophagus and the pharynx. The fleas regurgitate the bacteria when they take their next blood meal. Bacteria are transmitted subcutaneously to humans by the bite of infected fleas, but also by air, especially during pandemics of disease. Infective flea bites produce the typical bubonic form of plague in humans. Y.pestis is very closely related to the gastrointestinal pathogen Yersinia pseudotuberculosis, and it has been proposed that Y.pestis evolved from Y.pseudotuberculosis 1,500-20,000 years ago.

Y. pestis strain Angola was isolated prior to 1985. It belongs to the Antiqua biovar and ferments rhamnose and melibiose, a property usually associated with Y.pseudotuberculosis. Strain Angola has been found to belong to a group of atypical Y. pestis strains with genotypic similarities intermediate between typical Y. pestis strains and Y. pseudotuberculosis strains. Genotypic studies indicate that strain Angola is the oldest Y. pestis strain analyzed to date. Y. pestis Angola harbours three plasmids similar to other typical Y. pestis isolates but that display unusual sizes. One of the critical virulence factors for Yersinia, the V antigen, has been shown to be different from that encoded by typical strains of Y. pestis. Angola has been shown to be virulent by aerosol in mice. Y. pestis Angola contains a deletion affecting the F1 operon.
Properties: Presence of flagella: No
Human pathogen: Yes
Interaction: Animal pathogen in Mammalia
Number of membranes: 2
Number of inteins:0
Statistics: Number of YERPG entries in the UniProt Knowledgebase: 3821 (600 in UniProtKB/Swiss-Prot + 3221 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    Angola
Genome structure:
• Chromosome EMBL accession number CP000901 (circular; 4,504,254 bp) (download entry)
• Plasmid pMT-pPCP EMBL accession number CP000900 (circular; 114,570 bp) (download entry)
• Plasmid new_pCD EMBL accession number CP000902 (circular; 68,190 bp) (download entry)
Reference(s):
[1] PubMed=20061468; [ NCBI , EBI , Israel , Japan ]
Eppinger M., Worsham P.L., Nikolich M.P., Riley D.R., Sebastian Y., Mou S., Achtman M., Lindler L.E., Ravel J. ;
"Genome sequence of the deep-rooted Yersinia pestis strain Angola reveals new insights into the evolution and pangenome of the plague bacterium.";
J. Bacteriol. 192:1685-1699(2010).
Web links:
Official genome site(s):
http://msc.jcvi.org/yersinia/yersinia_pestis_angola/index.shtml
Other web sites:
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=16067
ERIC: http://www.ericbrc.org/portal/eric/yersiniapestisbiovarantiquaangola
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Ypes_Angola
 EBI Proteome Analysis page



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