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HAMAP annotation rule: MF_00001
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General rule information

Accession MF_00001
Dates 1-JUN-2001 (Created)
10-MAY-2011 (Last updated, Version 29)
Data class Protein
Predictors HAMAP; MF_00001; [distribution of match scores in UniProtKB];[seed alignment for MF_00001]
Names Asp_carb_tr


Propagated annotation

Identifier, protein and gene names
Identifier PYRB
Protein name
RecName: Full=Aspartate carbamoyltransferase;
EC=2.1.3.2;
AltName: Full=Aspartate transcarbamylase;
Short=ATCase;
Gene name pyrB
Comments
CATALYTIC ACTIVITY: Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.
PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.

case <OC:Archaea>
SUBUNIT: Heterooligomer of catalytic and regulatory chains (By similarity).
end case

SIMILARITY: Belongs to the ATCase/OTCase family.
Cross-references
Pfam PF00185; OTCace; 1;
TIGRFAMs TIGR00670; Asp_carb_tr; 1;
PROSITE PS00097; CARBAMOYLTRANSFERASE; 1;
Keywords
Pyrimidine biosynthesis, Transferase.
Gene Ontology
GO:0004070; Molecular function: aspartate carbamoyltransferase activity.
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process.


Additional information

Size range: 291-475 amino acids
Related UniRules: None
Template: P0A786 (PYRB_ECOLI); P05654 (PYRB_BACSU); Q58976 (PYRB_METJA); Q55338 (PYRB_SULAC): [Recover all]
Scope: Bacteria
Archaea
Fusion: Nter: None; Cter: MF_00002 (pyrI)
Duplicate: in SHEHH
Plasmid encoded: None
Comments: Possible wrong start in LACLE and SYNY3. Why no pyrB in TREPA?

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UniProtKB rule member sequences