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HAMAP rule MF_00004
General rule information
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Accession | MF_00004 |
Dates | 1-JUN-2001 (Created)
14-MAY-2024 (Last updated, Version 32) |
Name | Aden_phosphoribosyltr |
Scope(s) |
Bacteria Archaea |
Template(s) | P69503 (APT_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00004 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | APT |
Protein name | RecName: Full=Adenine phosphoribosyltransferase; Short=APRT; EC=2.4.2.7; |
Gene name | Name=apt; |
Comments
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FUNCTION | Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. |
CATALYTIC ACTIVITY | Reaction=AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine; Xref=Rhea:RHEA:16609, ChEBI:CHEBI:16708, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017, ChEBI:CHEBI:456215; EC=2.4.2.7; |
PATHWAY | Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. |
SUBUNIT | Homodimer. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the purine/pyrimidine phosphoribosyltransferase family. |
Keywords
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Gene Ontology
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GO:0003999; Molecular function:adenine phosphoribosyltransferase activity |
GO:0044209; Biological process:AMP salvage |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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Additional information
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Size range | 150-280 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |