Annotation rule MF_00005
Send feedback

General rule information [?]

Accession MF_00005
Dates 1-JUN-2001 (Created)
15-FEB-2013 (Last updated, Version 37)
Name Arg_succ_synth_type1
Scope Bacteria
Archaea

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ASSY
Protein name
RecName: Full=Argininosuccinate synthase;
EC=6.3.4.5;
AltName: Full=Citrulline--aspartate ligase;
Gene name
argG

Comments [?]

Catalytic activity ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.
Pathway Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate; step 2/3.
Subunit Homotetramer (By similarity).
Subcellular location Cytoplasm (By similarity).
Similarity Belongs to the argininosuccinate synthase family. Type 1 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0004055; Molecular function: argininosuccinate synthase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006526; Biological process: arginine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00764; Arginosuc_synth; 1;
TIGRFAMs TIGR00032; argG; 1;
PROSITE PS00564; ARGININOSUCCIN_SYN_1; 1;
PS00565; ARGININOSUCCIN_SYN_2; 1;

Features [?]

From: ASSY_THET8 (P59846)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     6     14       ATP (By similarity)        
BINDING (Optional)     33     33       ATP; via amide nitrogen and carbonyl oxygen (By similarity)     A  
BINDING     84     84       Citrulline (By similarity)     Y  
BINDING (Optional)     89     89       Citrulline (By similarity)     S  
BINDING     114     114       ATP; via amide nitrogen (By similarity)     G  
BINDING     116     116       Aspartate (By similarity)     T  
BINDING     120     120       Citrulline (By similarity)     N  
BINDING     120     120       Aspartate (By similarity)     N  
BINDING     121     121       Aspartate (By similarity)     D  
BINDING     124     124       Citrulline (By similarity)     R  
BINDING     173     173       Citrulline (By similarity)     S  
BINDING (Optional)     182     182       Citrulline (By similarity)     S  
BINDING     258     258       Citrulline (By similarity)     E  
BINDING     270     270       Citrulline (By similarity)     Y  

Additional information [?]

Size range 390-447 amino acids
Related rules MF_00581 (ASSY)
Templates P59846 (ASSY_THET8); Q9X2A1 (ASSY_THEMA): [Recover all]
Fusion None
Comments Argininosuccinate synthase type 2 subfamily in MF_00581.