HAMAP rule MF_00005
General rule information
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| Accession | MF_00005 |
| Dates | 1-JUN-2001 (Created)
28-NOV-2023 (Last updated, Version 44) |
| Name | Arg_succ_synth_type1 |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P59846 (ASSY_THET8); Q9X2A1 (ASSY_THEMA); [ Recover all ] |
| Triggered by |
HAMAP; MF_00005 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ASSY |
| Protein name | RecName: Full=Argininosuccinate synthase; EC=6.3.4.5; AltName: Full=Citrulline--aspartate ligase; |
| Gene name | Name=argG; |
Comments
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| CATALYTIC ACTIVITY | Reaction=ATP + L-aspartate + L-citrulline = 2-(N(omega)-L- arginino)succinate + AMP + diphosphate + H(+); Xref=Rhea:RHEA:10932, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57472, ChEBI:CHEBI:57743, ChEBI:CHEBI:456215; EC=6.3.4.5; |
| PATHWAY | Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. |
| SUBUNIT | Homotetramer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the argininosuccinate synthase family. Type 1 subfamily. |
Keywords
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Gene Ontology
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| GO:0004055; Molecular function:argininosuccinate synthase activity |
| GO:0005524; Molecular function:ATP binding |
| GO:0006526; Biological process:arginine biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF00764; Arginosuc_synth; 1; |
| NCBIfam | TIGR00032; argG; 1; |
| PROSITE | PS00564; ARGININOSUCCIN_SYN_1; 1; |
| PROSITE | PS00565; ARGININOSUCCIN_SYN_2; 1; |
Features
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| From: ASSY_THET8 (P59846) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 6 | 14 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
|||||||||
| BINDING | 33 | 33 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
A | ||||||||
| BINDING | 84 | 84 | /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743" |
Y | ||||||||
| BINDING | 89 | 89 | /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743" |
S | ||||||||
| BINDING | 114 | 114 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G | ||||||||
| BINDING | 116 | 116 | /ligand="L-aspartate" /ligand_id="ChEBI:CHEBI:29991" |
T | ||||||||
| BINDING | 120 | 120 | /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743" |
N | ||||||||
| BINDING | 120 | 120 | /ligand="L-aspartate" /ligand_id="ChEBI:CHEBI:29991" |
N | ||||||||
| BINDING | 121 | 121 | /ligand="L-aspartate" /ligand_id="ChEBI:CHEBI:29991" |
D | ||||||||
| BINDING | 124 | 124 | /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743" |
R | ||||||||
| BINDING | 173 | 173 | /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743" |
S | ||||||||
| BINDING | 182 | 182 | /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743" |
S | ||||||||
| BINDING | 258 | 258 | /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743" |
E | ||||||||
| BINDING | 270 | 270 | /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743" |
Y | ||||||||
Additional information
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| Size range | 390-447 amino acids |
| Related rules |
MF_00581 |
| Fusion | Nter: None Cter: None |
| Comments | Argininosuccinate synthase type 2 subfamily in MF_00581. |