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Annotation rule MF_00005
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General rule information [?]

Accession MF_00005
Dates 1-JUN-2001 (Created)
26-SEP-2014 (Last updated, Version 38)
Name Arg_succ_synth_type1
Scope Bacteria
Templates P59846 (ASSY_THET8); Q9X2A1 (ASSY_THEMA): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Argininosuccinate synthase;
AltName: Full=Citrulline--aspartate ligase;
Gene name

Comments [?]

Catalytic activity ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.
Pathway Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate; step 2/3.
Subunit Homotetramer.
Subcellular location Cytoplasm.
Similarity Belongs to the argininosuccinate synthase family. Type 1 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004055; Molecular function: argininosuccinate synthase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006526; Biological process: arginine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00764; Arginosuc_synth; 1;
TIGRFAMs TIGR00032; argG; 1;

Features [?]

From: ASSY_THET8 (P59846)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     6     14       ATP        
BINDING (Optional)     33     33       ATP; via amide nitrogen and carbonyl oxygen     A  
BINDING     84     84       Citrulline     Y  
BINDING (Optional)     89     89       Citrulline     S  
BINDING     114     114       ATP; via amide nitrogen     G  
BINDING     116     116       Aspartate     T  
BINDING     120     120       Citrulline     N  
BINDING     120     120       Aspartate     N  
BINDING     121     121       Aspartate     D  
BINDING     124     124       Citrulline     R  
BINDING     173     173       Citrulline     S  
BINDING (Optional)     182     182       Citrulline     S  
BINDING     258     258       Citrulline     E  
BINDING     270     270       Citrulline     Y  

Additional information [?]

Size range 390-447 amino acids
Related rules MF_00581 (ASSY)
Fusion None
Comments Argininosuccinate synthase type 2 subfamily in MF_00581.