To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
Annotation rule MF_00005
Send feedback

General rule information [?]

Accession MF_00005
Dates 1-JUN-2001 (Created)
26-SEP-2014 (Last updated, Version 38)
Name Arg_succ_synth_type1
Scope Bacteria
Templates P59846 (ASSY_THET8); Q9X2A1 (ASSY_THEMA): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Argininosuccinate synthase;
AltName: Full=Citrulline--aspartate ligase;
Gene name

Comments [?]

Catalytic activity ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.
Pathway Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.
Subunit Homotetramer.
Subcellular location Cytoplasm.
Similarity Belongs to the argininosuccinate synthase family. Type 1 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004055; Molecular function: argininosuccinate synthase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006526; Biological process: arginine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00764; Arginosuc_synth; 1;
TIGRFAMs TIGR00032; argG; 1;

Features [?]

From: ASSY_THET8 (P59846)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     6     14       ATP        
BINDING (Optional)     33     33       ATP; via amide nitrogen and carbonyl oxygen     A  
BINDING     84     84       Citrulline     Y  
BINDING (Optional)     89     89       Citrulline     S  
BINDING     114     114       ATP; via amide nitrogen     G  
BINDING     116     116       Aspartate     T  
BINDING     120     120       Citrulline     N  
BINDING     120     120       Aspartate     N  
BINDING     121     121       Aspartate     D  
BINDING     124     124       Citrulline     R  
BINDING     173     173       Citrulline     S  
BINDING (Optional)     182     182       Citrulline     S  
BINDING     258     258       Citrulline     E  
BINDING     270     270       Citrulline     Y  

Additional information [?]

Size range 390-447 amino acids
Related rules MF_00581 (ASSY)
Fusion None
Comments Argininosuccinate synthase type 2 subfamily in MF_00581.