HAMAP

Accession	MF_00005
Dates	1-JUN-2001 (Created) 26-MAY-2011 (Last updated, Version 36)

Data class

Protein

Predictors

HAMAP; MF_00005; [distribution of match scores in UniProtKB];[seed alignment for MF_00005]

Names

Arg_succ_synth_type1

Identifier

ASSY

Protein name

RecName: Full=Argininosuccinate synthase; EC=6.3.4.5; AltName: Full=Citrulline--aspartate ligase;

Gene name

argG

CATALYTIC ACTIVITY: ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.

PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.

SUBUNIT: Homotetramer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the argininosuccinate synthase family. Type 1 subfamily.

Pfam	PF00764; Arginosuc_synth; 1;
TIGRFAMs	TIGR00032; ArgG; 1;
PROSITE	PS00564; ARGININOSUCCIN_SYN_1; 1; PS00565; ARGININOSUCCIN_SYN_2; 1;

Cytoplasm, Amino-acid biosynthesis, Arginine biosynthesis, Ligase, ATP-binding, Nucleotide-binding.

GO:0004055; Molecular function: argininosuccinate synthase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006526; Biological process: arginine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: ASSY_THET8 (P59846)
Key		From		To		Description		Condition		FTGroup
NP_BIND		6		14		ATP (By similarity)
BINDING (Optional)		33		33		ATP; via amide nitrogen and carbonyl oxygen (By similarity)		A
BINDING		84		84		Citrulline (By similarity)		Y
BINDING (Optional)		89		89		Citrulline (By similarity)		S
BINDING		114		114		ATP; via amide nitrogen (By similarity)		G
BINDING		116		116		Aspartate (By similarity)		T
BINDING		120		120		Citrulline (By similarity)		N
BINDING		120		120		Aspartate (By similarity)		N
BINDING		121		121		Aspartate (By similarity)		D
BINDING		124		124		Citrulline (By similarity)		R
BINDING		173		173		Citrulline (By similarity)		S
BINDING (Optional)		182		182		Citrulline (By similarity)		S
BINDING		258		258		Citrulline (By similarity)		E
BINDING		270		270		Citrulline (By similarity)		Y

Size range:	390-447 amino acids
Related UniRules:	MF_00581 (ASSY)
Template:	P59846 (ASSY_THET8); Q9X2A1 (ASSY_THEMA): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in RHIL3
Plasmid encoded:	None
Comments:	Argininosuccinate synthase type 2 subfamily in MF_00581.