HAMAP

Accession	MF_00016
Dates	1-JUN-2001 (Created) 30-JUN-2011 (Last updated, Version 25)

Data class

Protein

Predictors

HAMAP; MF_00016; [distribution of match scores in UniProtKB];[seed alignment for MF_00016]

Names

DNA_helic_RuvB

Identifier

RUVB

Protein name

RecName: Full=Holliday junction ATP-dependent DNA helicase RuvB; EC=3.6.4.12;

Gene name

ruvB

FUNCTION: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity).

CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.

SUBUNIT: Forms a complex with RuvA (By similarity).

SIMILARITY: Belongs to the RuvB family.

Pfam	PF00004; AAA; 1;
TIGRFAMs	TIGR00635; RuvB; 1;

DNA damage, DNA repair, SOS response, ATP-binding, Nucleotide-binding, DNA recombination, Hydrolase, Helicase.

GO:0005524; Molecular function: ATP binding.
GO:0009378; Molecular function: four-way junction helicase activity.
GO:0006310; Biological process: DNA recombination.
GO:0006281; Biological process: DNA repair.
GO:0009432; Biological process: SOS response.

From: RUVB_ECOLI (P0A812)
Key		From		To		Description		Condition		FTGroup
NP_BIND		62		69		ATP (Potential)		G-x-x-G-x-G-K-T

Size range:	307-386 amino acids
Related UniRules:	None
Template:	P0A812 (RUVB_ECOLI); Q5SL87 (RUVB_THET8): [Recover all]
Scope:	Bacteria Archaea; Methanomicrobiales
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None