HAMAP

Accession	MF_00031
Dates	1-JUN-2001 (Created) 18-AUG-2011 (Last updated, Version 22)

Data class

Protein

Predictors

HAMAP; MF_00031; [distribution of match scores in UniProtKB];[seed alignment for MF_00031]

Names

DNA_helic_RuvA

Identifier

RUVA

Protein name

RecName: Full=Holliday junction ATP-dependent DNA helicase RuvA; EC=3.6.4.12;

Gene name

ruvA

FUNCTION: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity).

CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.

SUBUNIT: Forms a complex with RuvB (By similarity).

SIMILARITY: Belongs to the RuvA family.

Pfam	PF00633; HHH; 0-1; PF07499; RuvA_C; 1; PF01330; RuvA_N; 1;
TIGRFAMs	TIGR00084; RuvA; 1;

ATP-binding, Nucleotide-binding, DNA damage, DNA repair, SOS response, DNA-binding, DNA recombination, Hydrolase, Helicase.

GO:0009378; Molecular function: four-way junction helicase activity.
GO:0006310; Biological process: DNA recombination.
GO:0006281; Biological process: DNA repair.
GO:0009432; Biological process: SOS response.

Size range:	183-227 amino acids
Related UniRules:	None
Template:	P0A809 (RUVA_ECOLI); P40832 (RUVA_MYCLE): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None