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HAMAP annotation rule: MF_00033
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General rule information

Accession MF_00033
Dates 1-JUN-2001 (Created)
10-MAY-2011 (Last updated, Version 41)
Data class Protein
Predictors HAMAP; MF_00033; [distribution of match scores in UniProtKB];[seed alignment for MF_00033]
Names MurG


Propagated annotation

Identifier, protein and gene names
Identifier MURG
Protein name
RecName: Full=UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase;
EC=2.4.1.227;
AltName: Full=Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase;
Gene name murG
Comments
FUNCTION: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) (By similarity).
CATALYTIC ACTIVITY: UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.
PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.

case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein (By similarity).

else case <Property:Membrane=2>
SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein (By similarity).
end case

SIMILARITY: Belongs to the glycosyltransferase 28 family. MurG subfamily.
Cross-references
Pfam PF04101; Glyco_tran_28_C; 1;
PF03033; Glyco_transf_28; 1;
TIGRFAMs TIGR01133; MurG; 1;
Keywords
Cell cycle, Cell division, Cell membrane, Cell shape, Cell wall biogenesis/degradation, Glycosyltransferase.

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane.
end case

Membrane, Peptidoglycan synthesis, Transferase.
Gene Ontology
GO:0050511; Molecular function: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity.
GO:0030259; Biological process: lipid glycosylation.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005886; Cellular component: plasma membrane.


Additional information

Size range: 333-441 amino acids
Related UniRules: None
Template: P17443 (MURG_ECOLI)
Scope: Bacteria
Fusion: Nter: None; Cter: None
Duplicate: in BACAH, BACAN, BACC1, BACCR, BACCZ, BACHK
Plasmid encoded: None

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UniProtKB rule member sequences