HAMAP

Accession	MF_00034
Dates	1-JUN-2001 (Created) 5-AUG-2011 (Last updated, Version 24)

Data class

Protein

Predictors

HAMAP; MF_00034; [distribution of match scores in UniProtKB];[seed alignment for MF_00034]

Names

RuvC

Identifier

RUVC

Protein name

RecName: Full=Crossover junction endodeoxyribonuclease RuvC; EC=3.1.22.4; AltName: Full=Holliday junction nuclease RuvC; AltName: Full=Holliday junction resolvase RuvC;

Gene name

ruvC

FUNCTION: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity).

CATALYTIC ACTIVITY: Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).

COFACTOR: Binds 1 magnesium ion per subunit (By similarity).

SIMILARITY: Belongs to the RuvC family.

Pfam	PF02075; RuvC; 1;
TIGRFAMs	TIGR00228; RuvC; 1;
PROSITE	PS01321; RUVC; 1;

Hydrolase, Nuclease, DNA damage, DNA repair, DNA recombination, Magnesium, Metal-binding.

GO:0008821; Molecular function: crossover junction endodeoxyribonuclease activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0006310; Biological process: DNA recombination.
GO:0006281; Biological process: DNA repair.

From: RUVC_ECOLI (P0A814)
Key		From		To		Description		Condition		FTGroup
METAL		8		8		Magnesium (By similarity)		D
METAL		67		67		Magnesium (By similarity)		E
METAL		139		139		Magnesium (By similarity)		[DH]
METAL		142		142		Magnesium (By similarity)		D

Size range:	154-223 amino acids
Related UniRules:	None
Template:	P0A814 (RUVC_ECOLI)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Possible wrong start in TREPA