Home Proteomes Families Hamap-Scan Documents Downloads Links
HAMAP annotation rule: MF_00038
Send feedback new

General rule information

Accession MF_00038
Dates 1-JUN-2001 (Created)
10-MAY-2011 (Last updated, Version 43)
Data class Protein
Predictors HAMAP; MF_00038; [distribution of match scores in UniProtKB];[seed alignment for MF_00038]
Names MraY


Propagated annotation

Identifier, protein and gene names
Identifier MRAY

case <OC:Bacteria>
Protein name
RecName: Full=Phospho-N-acetylmuramoyl-pentapeptide-transferase;
EC=2.7.8.13;
AltName: Full=UDP-MurNAc-pentapeptide phosphotransferase;
Gene name mraY

else case <OC:Archaea>
Protein name
RecName: Full=Putative phospho-N-acetylmuramoyl-pentapeptide-transferase;
EC=2.7.8.13;
AltName: Full=UDP-MurNAc-pentapeptide phosphotransferase;
end case

Comments

case <OC:Bacteria>
FUNCTION: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity).
end case

CATALYTIC ACTIVITY: UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.

case <OC:Bacteria>
PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
end case


case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).

else case <Property:Membrane=2>
SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).
end case

SIMILARITY: Belongs to the glycosyltransferase 4 family. MraY subfamily.
Cross-references
Pfam PF00953; Glycos_transf_4; 1;
TIGRFAMs TIGR00445; MraY; 1;
PROSITE PS01347; MRAY_1; 1;
PS01348; MRAY_2; 1;
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
General Transmembrane; -; 10; trigger=Yes;
ADD_TOPO_DOMAIN Periplasmic; -; 6; trigger=Yes;
Cytoplasmic; -; 5; trigger=Yes;
else
General Transmembrane; -; 8-11; trigger=Yes;
end case

Keywords

case <OC:Bacteria>
Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis.
end case


case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane.
end case

Cell membrane, Membrane, Transferase, Transmembrane, Transmembrane helix.
Gene Ontology
GO:0008963; Molecular function: phospho-N-acetylmuramoyl-pentapeptide-transferase activity.

case <OC:Bacteria>
GO:0009252; Biological process: peptidoglycan biosynthetic process.
end case

GO:0005886; Cellular component: plasma membrane.


Additional information

Size range: 302-422 amino acids
Related UniRules: None
Template: P0A6W3 (MRAY_ECOLI); Q2FZ93 (MRAY_STAA8): [Recover all]

case <Property:PEPTIDOGL_BS>
Scope: Bacteria
end case

Scope: Archaea
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None
Comments: Very divergent TREPA

View rule in raw text format (no links)



UniProtKB rule member sequences