HAMAP rule MF_00038
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00038 |
| Accession | MF_00038 |
| Dates | 1-JUN-2001 (Created)
17-DEC-2024 (Last updated, Version 53) |
| Name | MraY |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P0A6W3 (MRAY_ECOLI); Q2FZ93 (MRAY_STAA8); O66465 (MRAY_AQUAE); [ Recover all ] |
| Triggered by |
HAMAP; MF_00038 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MRAY |
| case <OC:Bacteria> | |
| Protein name | RecName: Full=Phospho-N-acetylmuramoyl-pentapeptide-transferase; EC=2.7.8.13; AltName: Full=UDP-MurNAc-pentapeptide phosphotransferase; |
| Gene name | Name=mraY; |
| else case <OC:Archaea> | |
| Protein name | RecName: Full=Putative phospho-N-acetylmuramoyl-pentapeptide-transferase; EC=2.7.8.13; AltName: Full=UDP-MurNAc-pentapeptide phosphotransferase; |
| end case | |
Comments
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| case <OC:Bacteria> | |
| FUNCTION | Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc- pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I. |
| end case | |
| case <OC:Lactobacillales> or <OC:Staphylococcus> | |
| CATALYTIC ACTIVITY | Reaction=UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L- lysyl-D-alanyl-D-alanine + di-trans,octa-cis-undecaprenyl phosphate = Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis- undecaprenyl diphosphate + UMP; Xref=Rhea:RHEA:21920, ChEBI:CHEBI:57865, ChEBI:CHEBI:60032, ChEBI:CHEBI:60392, ChEBI:CHEBI:70758; EC=2.7.8.13; |
| else | |
| CATALYTIC ACTIVITY | Reaction=UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso- 2,6-diaminopimeloyl-D-alanyl-D-alanine + di-trans,octa-cis- undecaprenyl phosphate = di-trans,octa-cis-undecaprenyl diphospho-N- acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl- D-alanyl-D-alanine + UMP; Xref=Rhea:RHEA:28386, ChEBI:CHEBI:57865, ChEBI:CHEBI:60392, ChEBI:CHEBI:61386, ChEBI:CHEBI:61387; EC=2.7.8.13; |
| end case | |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| case <OC:Bacteria> | |
| PATHWAY | Cell wall biogenesis; peptidoglycan biosynthesis. |
| end case | |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the glycosyltransferase 4 family. MraY subfamily. |
Keywords
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| case <OC:Bacteria> | |
| Cell cycle | |
| Cell division | |
| Cell shape | |
| Cell wall biogenesis/degradation | |
| Peptidoglycan synthesis | |
| end case | |
| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Cell membrane | |
| Magnesium | |
| Membrane | |
| Metal-binding | |
| Transferase | |
| Transmembrane | |
| Transmembrane helix | |
Gene Ontology
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| GO:0008963; Molecular function:phospho-N-acetylmuramoyl-pentapeptide-transferase activity | |
| case <OCellular component:Bacteria> | |
| GO:0009252; Biological process:peptidoglycan biosynthetic process | |
| end case | |
| GO:0005886; Cellular component:plasma membrane | |
Cross-references
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| Pfam | PF00953; Glycos_transf_4; 1; |
| NCBIfam | TIGR00445; MraY; 1; |
| PROSITE | PS01347; MRAY_1; 1; |
| PROSITE | PS01348; MRAY_2; 1; |
| General | Transmembrane; -; 10; |
| ADD_TOPO_DOMAIN | Periplasmic; -; 6; |
| ADD_TOPO_DOMAIN | Cytoplasmic; -; 5; |
| General | Transmembrane; -; 8-11; |
Features
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Additional information
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| Size range | 302-422 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Very divergent TREPA |