HAMAP rule MF_00039
General rule information
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| Accession | MF_00039 |
| Dates | 1-JUN-2001 (Created)
23-NOV-2023 (Last updated, Version 29) |
| Name | Adenylate_kinase_AK6 |
| Scope(s) |
Archaea |
| Template(s) | Q9UZK4 (KAD6_PYRAB); Q9Y3D8 (KAD6_HUMAN); [ Recover all ] |
| Triggered by |
case c? <OC:Archaea>
HAMAP; MF_00039 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | KAD6 |
| Protein name | RecName: Full=Putative adenylate kinase; Short=AK; EC=2.7.4.3; AltName: Full=ATP-AMP transphosphorylase; |
Comments
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| FUNCTION | Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late maturation steps of the 30S ribosomal particles, specifically 16S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. |
| CATALYTIC ACTIVITY | Reaction=AMP + ATP = 2 ADP; Xref=Rhea:RHEA:12973, ChEBI:CHEBI:30616, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.4.3; |
| CATALYTIC ACTIVITY | Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; |
| SUBUNIT | Interacts with uS11. Not a structural component of 40S pre- ribosomes, but transiently interacts with them by binding to uS11. |
| SIMILARITY | Belongs to the adenylate kinase family. AK6 subfamily. |
Keywords
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Gene Ontology
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| GO:0004017; Molecular function:adenylate kinase activity |
| GO:0005524; Molecular function:ATP binding |
| GO:0042274; Biological process:ribosomal small subunit biogenesis |
Cross-references
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Features
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| From: KAD6_PYRAB (Q9UZK4) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 30 | 50 | /note="NMP" | |||||||||
| REGION | 99 | 109 | /note="LID" | |||||||||
| BINDING | 10 | 10 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G | ||||||||
| BINDING | 12 | 12 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G | ||||||||
| BINDING | 13 | 13 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
K | ||||||||
| BINDING | 14 | 14 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[ST] | ||||||||
| BINDING | 15 | 15 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[STIVY] | ||||||||
| BINDING | 100 | 100 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
R | ||||||||
| BINDING | 138 | 138 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
K | ||||||||
Additional information
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| Size range | 148-196 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Has homologs in eukaryotes |