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HAMAP annotation rule: MF_00044
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General rule information

Accession MF_00044
Dates 1-JUN-2001 (Created)
21-NOV-2011 (Last updated, Version 30)
Data class Protein

case <OC:Bacteria>
Predictors HAMAP; MF_00044_B; [distribution of match scores in UniProtKB];[seed alignment for MF_00044_B]
end case


case <OC:Archaea>
Predictors HAMAP; MF_00044_A; [distribution of match scores in UniProtKB];[seed alignment for MF_00044_A]
end case

Names Asp_tRNA_synth


Propagated annotation

Identifier, protein and gene names
Identifier SYD
Protein name
RecName: Full=Aspartate--tRNA ligase;
EC=6.1.1.12;
AltName: Full=Aspartyl-tRNA synthetase;
Short=AspRS;
Gene name aspS
Comments
CATALYTIC ACTIVITY: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp).

case <OC:Archaea>
COFACTOR: Binds 3 magnesium ions per subunit (By similarity).
end case


case <OC:Bacteria>
SUBUNIT: Homodimer (By similarity).
end case

SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
Cross-references
Pfam PF00152; tRNA-synt_2; 1;
PRINTS PR01042; TRNASYNTHASP; 1;
TIGRFAMs TIGR00458; AspS_arch; 1;
TIGR00459; AspS_bact; 1;
PROSITE PS50862; AA_TRNA_LIGASE_II; 1;
Keywords
Cytoplasm, Aminoacyl-tRNA synthetase, Protein biosynthesis, Ligase, ATP-binding, Nucleotide-binding.

case <OC:Archaea>
Magnesium, Metal-binding.
end case

Gene Ontology
GO:0004815; Molecular function: aspartate-tRNA ligase activity.
GO:0005524; Molecular function: ATP binding.

case <OC:Archaea>
GO:0000287; Molecular function: magnesium ion binding.
end case

GO:0006422; Biological process: aspartyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.
Features

case <OC:Archaea>
From: SYD_PYRKO (Q52428)
Key     From     To       Description   Condition   FTGroup
METAL     361     361       Magnesium 2 (By similarity)   E  
METAL     361     361       Magnesium 3 (By similarity)   E  
METAL     364     364       Magnesium 2 (By similarity)   [ST]  
end case



Additional information


case <OC:Bacteria>
Size range: 550-629 amino acids
end case


case <OC:Archaea>
Size range: 423-444 amino acids
end case

Related UniRules: MF_00534 (SYN)
Template: P21889 (SYD_ECOLI); P36419 (SYD_THETH); Q52428 (SYD_PYRKO): [Recover all]
Scope: Bacteria
Archaea
Fusion: Nter: <Unknown>; Cter: None
Duplicate: in STRMU, SYNAS
Plasmid encoded: None
Comments: Possible wrong start site in TREPA. Unknown N-terminal domain in MAGSA

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UniProtKB rule member sequences