HAMAP rule MF_00046
General rule information
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Accession | MF_00046 |
Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 43) |
Name | MurC |
Scope(s) |
Bacteria |
Template(s) | P17952 (MURC_ECOLI); Q9WY73 (MURC_THEMA); [ Recover all ] |
Triggered by |
HAMAP; MF_00046 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MURC |
Protein name | RecName: Full=UDP-N-acetylmuramate--L-alanine ligase; EC=6.3.2.8; AltName: Full=UDP-N-acetylmuramoyl-L-alanine synthetase; |
Gene name | Name=murC; |
Comments
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FUNCTION | Cell wall formation. |
CATALYTIC ACTIVITY | Reaction=ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine; Xref=Rhea:RHEA:23372, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57972, ChEBI:CHEBI:70757, ChEBI:CHEBI:83898, ChEBI:CHEBI:456216; EC=6.3.2.8; |
PATHWAY | Cell wall biogenesis; peptidoglycan biosynthesis. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the MurCDEF family. |
Keywords
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ATP-binding |
Cell cycle |
Cell division |
Cell shape |
Cell wall biogenesis/degradation |
Cytoplasm |
Ligase |
Nucleotide-binding |
Peptidoglycan synthesis |
Gene Ontology
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GO:0005524; Molecular function:ATP binding |
GO:0008763; Molecular function:UDP-N-acetylmuramate-L-alanine ligase activity |
GO:0009252; Biological process:peptidoglycan biosynthetic process |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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From: MURC_ECOLI (P17952) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 126 | 132 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-x(2)-G-K-[ST]-[STG] |
Additional information
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Size range | 431-539 amino acids |
Related rules |
MF_00208 |
Fusion | Nter: None Cter: MF_00047 (ddl) |
Comments | Weird insertion in NOSS1 and SYNY3. Probable wrong start in LACLA. |