HAMAP

Accession	MF_00053
Dates	1-JUN-2001 (Created) 9-DEC-2011 (Last updated, Version 20)

Data class

Protein

Predictors

HAMAP; MF_00053; [distribution of match scores in UniProtKB];[seed alignment for MF_00053]

Names

RNase_HIII

Identifier

RNH3

Protein name

RecName: Full=Ribonuclease HIII; Short=RNase HIII; EC=3.1.26.4;

Gene name

rnhC

FUNCTION: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids (By similarity).

CATALYTIC ACTIVITY: Endonucleolytic cleavage to 5'-phosphomonoester.

COFACTOR: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (Potential).

SIMILARITY: Belongs to the RNase HII family. RnhC subfamily.

Pfam	PF01351; RNase_HII; 1;
TIGRFAMs	TIGR00716; RnhC; 1;

Cytoplasm, Hydrolase, Nuclease, Endonuclease, Magnesium, Metal-binding.

GO:0000287; Molecular function: magnesium ion binding.
GO:0004523; Molecular function: ribonuclease H activity.
GO:0006401; Biological process: RNA catabolic process.
GO:0005737; Cellular component: cytoplasm.

From: RNH3_BACSU (P94541)
Key		From		To		Description		Condition		FTGroup
METAL		100		100		Divalent metal cation (By similarity)		D
METAL		101		101		Divalent metal cation (By similarity)		E
METAL		205		205		Divalent metal cation (By similarity)		D

Size range:	257-316 amino acids
Related UniRules:	None
Template:	P94541 (RNH3_BACSU)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None