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| HAMAP annotation rule MF_00054 |
| Accession | MF_00054 |
| Dates | 1-JUN-2001 (Created) 11-MAY-2011 (Last updated, Version 26) |
| Name | EF-G_EF-2 |
| Scope | Bacteria Archaea |
case <OC:Bacteria>
| Triggered by |
end case
case <OC:Archaea>
| Triggered by |
end case
case <OC:Bacteria>
| Identifier |
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| Protein name |
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end case
case <OC:Archaea>
| Identifier |
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| Protein name |
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end case
| Gene name |
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| FUNCTION | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity). |
| SUBCELLULAR LOCATION | Cytoplasm (By similarity). |
| SIMILARITY | Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily. |
case <FT:4> or <FT:5>
end case
GO:0005525; Molecular function: GTP binding.
GO:0003746; Molecular function: translation elongation factor activity.
GO:0006414; Biological process: translational elongation.
GO:0005737; Cellular component: cytoplasm.
GO:0003746; Molecular function: translation elongation factor activity.
GO:0006414; Biological process: translational elongation.
GO:0005737; Cellular component: cytoplasm.
| Pfam | PF00679; EFG_C; 1; |
| PF00009; GTP_EFTU; 1; | |
| PF03144; GTP_EFTU_D2; 1; | |
| PRINTS | PR00315; ELONGATNFCT; 1; |
| TIGRFAMs | TIGR00231; Small_GTP; 1; |
| TIGR00484; EF-G; 1; | |
| TIGR00490; AEF-2; 1; | |
| PROSITE | PS00301; EFACTOR_GTP; 1; |
case <OC:Bacteria>
| From: EFG_ECOLI (P0A6M8) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| NP_BIND | 17 | 24 | GTP (By similarity) | |||||||||
| NP_BIND | 88 | 92 | GTP (By similarity) | |||||||||
| NP_BIND | 142 | 145 | GTP (By similarity) | |||||||||
end case
case <OC:Escherichia> or <OC:Shigella>
end case
case <OC:Archaea>
| From: EF2_SULSO (P30925) | ||||||||||||
| NP_BIND | 27 | 34 | GTP (By similarity) | |||||||||
| NP_BIND | 93 | 97 | GTP (By similarity) | |||||||||
| NP_BIND | 147 | 150 | GTP (By similarity) | |||||||||
| MOD_RES | 603 | 603 | Diphthamide (By similarity) | H | ||||||||
end case
case <OC:Bacteria>
| Size range: | 669-715 amino acids |
end case
case <OC:Archaea>
| Size range: | 726-743 amino acids |
end case
| Related Rules: | None |
| Templates: | P0A6M8 (EFG_ECOLI); P13551 (EFG_THETH); P30925 (EF2_SULSO): [Recover all] |
| Fusion: | None |
| Comments: | EFG2_BORBU could be made slightly longer in the N-terminal (MVVVGDL) by frameshifting just before the current initiator Met |