Annotation rule MF_00054
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General rule information [?]

Accession MF_00054
Dates 1-JUN-2001 (Created)
18-FEB-2014 (Last updated, Version 29)
Name EF_G_EF_2
Scope Bacteria
Archaea
case <OC:Bacteria>
end case

case <OC:Archaea>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Bacteria>
Identifier
EFG
Protein name
RecName: Full=Elongation factor G;
Short=EF-G;
end case
case <OC:Archaea>
Identifier
EF2
Protein name
RecName: Full=Elongation factor 2;
Short=EF-2;
end case
Gene name
fusA

Comments [?]

Function Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
Subcellular location Cytoplasm (By similarity).
Similarity Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0005525; Molecular function: GTP binding.
GO:0003746; Molecular function: translation elongation factor activity.
GO:0006414; Biological process: translational elongation.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00679; EFG_C; 1;
PF00009; GTP_EFTU; 1;
PF03144; GTP_EFTU_D2; 1;
PRINTS PR00315; ELONGATNFCT; 1;
TIGRFAMs TIGR00231; Small_GTP; 1;
TIGR00484; EF-G; 1;
TIGR00490; AEF-2; 1;
PROSITE PS00301; EFACTOR_GTP; 1;

Features [?]

case <OC:Bacteria>
From: EFG_ECOLI (P0A6M8)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     17     24       GTP (By similarity)     [AS]-H-[IV]-D-[AS]-G-K-T  
NP_BIND     88     92       GTP (By similarity)     D-T-P-G-H  
NP_BIND     142     145       GTP (By similarity)     N-K-x-D  
end case
case <OC:Archaea>
From: EF2_SULSO (P30925)
NP_BIND     27     34       GTP (By similarity)     A-H-[IV]-[DH]-H-G-K-T  
NP_BIND     93     97       GTP (By similarity)     D-T-P-G-H  
NP_BIND     147     150       GTP (By similarity)     N-K-[IV]-D  
MOD_RES     603     603       Diphthamide (By similarity)     H  
end case

Additional information [?]

case <OC:Bacteria>
Size range 669-715 amino acids
end case
case <OC:Archaea>
Size range 726-743 amino acids
end case
Related rules MF_03063 (EFGC supersedes the current rule)
Templates P0A6M8 (EFG_ECOLI); P13551 (EFG_THETH); P30925 (EF2_SULSO): [Recover all]
Fusion None
Comments EFG2_BORBU could be made slightly longer in the N-terminal (MVVVGDL) by frameshifting just before the current initiator Met