HAMAP

Accession	MF_00057
Dates	1-JUN-2001 (Created) 10-OCT-2011 (Last updated, Version 24)

Data class

Protein

Predictors

HAMAP; MF_00057; [distribution of match scores in UniProtKB];[seed alignment for MF_00057]

Names

CMP-KDO_synth

Identifier

KDSB

Protein name

RecName: Full=3-deoxy-manno-octulosonate cytidylyltransferase; EC=2.7.7.38; AltName: Full=CMP-2-keto-3-deoxyoctulosonic acid synthase; Short=CKS; Short=CMP-KDO synthase;

Gene name

kdsB

FUNCTION: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity).

CATALYTIC ACTIVITY: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate.

PATHWAY: Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1.

PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.

SUBCELLULAR LOCATION: Cytoplasm (Potential).

SIMILARITY: Belongs to the KdsB family.

TIGRFAMs

TIGR00466; KdsB; 1;

Cytoplasm, Lipopolysaccharide biosynthesis, Transferase, Nucleotidyltransferase.

GO:0008690; Molecular function: 3-deoxy-manno-octulosonate cytidylyltransferase activity.
GO:0009103; Biological process: lipopolysaccharide biosynthetic process.
GO:0019294; Biological process: keto-3-deoxy-D-manno-octulosonic acid biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Size range:	234-289 amino acids
Related UniRules:	None
Template:	P04951 (KDSB_ECOLI); P42216 (KPSU5_ECOLX): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in ACTP2, BURCM, BURA4, BURPP, BURS3, THICR
Plasmid encoded:	None
Comments:	kpsU from E.coli (KPSU5_ECOLX) is not a duplicate, but a kdsB from a non-K12 strain