HAMAP

Accession	MF_00060
Dates	1-JUN-2001 (Created) 9-DEC-2011 (Last updated, Version 31)

Data class

Protein

Predictors

HAMAP; MF_00060; [distribution of match scores in UniProtKB];[seed alignment for MF_00060]

Names

SurE

Identifier

SURE

Protein name

RecName: Full=5'/3'-nucleotidase SurE; EC=3.1.3.5; EC=3.1.3.6; AltName: Full=Exopolyphosphatase; EC=3.6.1.11; AltName: Full=Nucleoside monophosphate phosphohydrolase;

Protein name

RecName: Full=5'-nucleotidase surE; EC=3.1.3.5; AltName: Full=Nucleoside 5'-monophosphate phosphohydrolase;

Gene name

surE

FUNCTION: Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs (By similarity).

CATALYTIC ACTIVITY: A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.

CATALYTIC ACTIVITY: A 3'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.

CATALYTIC ACTIVITY: (Polyphosphate)(n) + H(2)O = (polyphosphate)(n-1) + phosphate.

FUNCTION: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity).

CATALYTIC ACTIVITY: A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.

COFACTOR: Binds 1 divalent metal cation per subunit (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (Potential).

SIMILARITY: Belongs to the surE nucleotidase family.

Pfam	PF01975; SurE; 1;
TIGRFAMs	TIGR00087; SurE; 1;

Cytoplasm, Hydrolase, Metal-binding, Nucleotide-binding.

GO:0008253; Molecular function: 5'-nucleotidase activity.

GO:0004309; Molecular function: exopolyphosphatase activity.
GO:0008254; Molecular function: 3'-nucleotidase activity.

GO:0046872; Molecular function: metal ion binding.
GO:0005737; Cellular component: cytoplasm.

From: SURE_THEMA (P96112)
Key		From		To		Description		Condition		FTGroup
METAL		8		8		Divalent metal cation (By similarity)		D
METAL		9		9		Divalent metal cation (By similarity)		D
METAL		39		39		Divalent metal cation (By similarity)		S
METAL		95		95		Divalent metal cation (By similarity)		N

Size range:	244-283 amino acids
Related UniRules:	None
Template:	P96112 (SURE_THEMA); P0A840 (SURE_ECOLI); Q8ZU79 (SURE1_PYRAE): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in BURS3, CHLCV, PYRAE, THET2
Plasmid encoded:	in THET2, THET8
Comments:	In some organisms, surE was originally annotated as an acid phosphatase (EC 3.1.3.2). Weird C-terminal sequence in TREPA; no obvious frameshift; not shown in alignment and not used in size range. There are divergent second copies of surE in NOSS1 (alr3139) and SYNY3 (sll1459).