HAMAP annotation rule MF_00067
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Accession MF_00067
Dates 1-JUN-2001 (Created)
11-MAY-2011 (Last updated, Version 23)
Name GmhA
Scope Bacteria
Archaea
Triggered by



Identifier
GMHA
case <OC:Bacteria>
Protein name
RecName: Full=Phosphoheptose isomerase;
EC=5.3.1.28;
AltName: Full=Sedoheptulose 7-phosphate isomerase;
end case
case <OC:Archaea>
Protein name
RecName: Full=Probable phosphoheptose isomerase;
EC=5.3.1.28;
AltName: Full=Sedoheptulose 7-phosphate isomerase;
end case
Gene name
gmhA


FUNCTION Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity).
CATALYTIC ACTIVITY D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate.
COFACTOR Binds 1 zinc ion per subunit (By similarity).
PATHWAY Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate; step 1/1.
case <OC:Proteobacteria>
SUBUNIT Homotetramer (By similarity).
end case
SUBCELLULAR LOCATION Cytoplasm (By similarity).
MISCELLANEOUS The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate (By similarity).
SIMILARITY Belongs to the SIS family. GmhA subfamily.


Cytoplasm
Carbohydrate metabolism
Isomerase
Metal-binding
Zinc


GO:0008270; Molecular function: zinc ion binding.
GO:0008968; Molecular function: D-sedoheptulose 7-phosphate isomerase activity.
GO:0005975; Biological process: carbohydrate metabolic process.
GO:0005737; Cellular component: cytoplasm.


PROSITE PS51464; SIS; 1; trigger=PRU00797;
Pfam PF01380; SIS; 1;
TIGRFAMs TIGR00441; GmhA; 1;


From: GMHA_BURPS (Q93UJ2)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     55     57       Substrate binding (By similarity)     N-x-G  
REGION     97     98       Substrate binding (By similarity)     N-D  
REGION     123     125       Substrate binding (By similarity)     [ST]-T-S  
METAL     64     64       Zinc (By similarity)     H  
METAL     68     68       Zinc (By similarity)     [EQN]  
METAL     175     175       Zinc (By similarity)     [QH]  
METAL     183     183       Zinc (By similarity)     H  
BINDING     68     68       Substrate (By similarity)     [EQN]  
BINDING     128     128       Substrate (By similarity)     S  
BINDING     175     175       Substrate (By similarity)     [QH]  


Size range: 182-231 amino acids
Related Rules: None
Templates: P63224 (GMHA_ECOLI); Q93UJ2 (GMHA_BURPS); Q9HVZ0 (GMHA_PSEAE); Q9AGY7 (GMHA_ANETH): [Recover all]
Fusion: None


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