HAMAP

Accession	MF_00067
Dates	1-JUN-2001 (Created) 11-MAY-2011 (Last updated, Version 23)

Data class

Protein

Predictors

HAMAP; MF_00067; [distribution of match scores in UniProtKB];[seed alignment for MF_00067]

Names

GmhA

Identifier

GMHA

Protein name

RecName: Full=Phosphoheptose isomerase; EC=5.3.1.28; AltName: Full=Sedoheptulose 7-phosphate isomerase;

Protein name

RecName: Full=Probable phosphoheptose isomerase; EC=5.3.1.28; AltName: Full=Sedoheptulose 7-phosphate isomerase;

Gene name

gmhA

FUNCTION: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity).

CATALYTIC ACTIVITY: D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate.

COFACTOR: Binds 1 zinc ion per subunit (By similarity).

PATHWAY: Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.

SUBUNIT: Homotetramer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

MISCELLANEOUS: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate (By similarity).

SIMILARITY: Belongs to the SIS family. GmhA subfamily.

PROSITE	PS51464; SIS; 1; trigger=PRU00797;
Pfam	PF01380; SIS; 1;
TIGRFAMs	TIGR00441; GmhA; 1;

Cytoplasm, Carbohydrate metabolism, Isomerase, Metal-binding, Zinc.

GO:0008270; Molecular function: zinc ion binding.
GO:0008968; Molecular function: D-sedoheptulose 7-phosphate isomerase activity.
GO:0005975; Biological process: carbohydrate metabolic process.
GO:0005737; Cellular component: cytoplasm.

From: GMHA_BURPS (Q93UJ2)
Key		From		To		Description		Condition		FTGroup
REGION		55		57		Substrate binding (By similarity)		N-x-G
REGION		97		98		Substrate binding (By similarity)		N-D
REGION		123		125		Substrate binding (By similarity)		[ST]-T-S
METAL		64		64		Zinc (By similarity)		H
METAL		68		68		Zinc (By similarity)		[EQN]
METAL		175		175		Zinc (By similarity)		[QH]
METAL		183		183		Zinc (By similarity)		H
BINDING		68		68		Substrate (By similarity)		[EQN]
BINDING		128		128		Substrate (By similarity)		S
BINDING		175		175		Substrate (By similarity)		[QH]

Size range:	182-231 amino acids
Related UniRules:	None
Template:	P63224 (GMHA_ECOLI); Q93UJ2 (GMHA_BURPS); Q9HVZ0 (GMHA_PSEAE); Q9AGY7 (GMHA_ANETH): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in CAMJE
Plasmid encoded:	None