HAMAP rule MF_00067
General rule information
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| Accession | MF_00067 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 32) |
| Name | GmhA |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P63224 (GMHA_ECOLI); Q93UJ2 (GMHA_BURPS); Q9HVZ0 (GMHA_PSEAE); Q9AGY7 (GMHA_ANETH); [ Recover all ] |
| Triggered by |
HAMAP; MF_00067 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GMHA |
| case <OC:Bacteria> | |
| Protein name | RecName: Full=Phosphoheptose isomerase; EC=5.3.1.28; AltName: Full=Sedoheptulose 7-phosphate isomerase; |
| end case | |
| case <OC:Archaea> | |
| Protein name | RecName: Full=Probable phosphoheptose isomerase; EC=5.3.1.28; AltName: Full=Sedoheptulose 7-phosphate isomerase; |
| end case | |
| Gene name | Name=gmhA; |
Comments
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| FUNCTION | Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. |
| CATALYTIC ACTIVITY | Reaction=2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno- heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate; Xref=Rhea:RHEA:27489, ChEBI:CHEBI:57483, ChEBI:CHEBI:60203, ChEBI:CHEBI:60204; EC=5.3.1.28; |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| PATHWAY | Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7- phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7- phosphate: step 1/1. |
| case <OC:Pseudomonadota> | |
| SUBUNIT | Homotetramer. |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| MISCELLANEOUS | The reaction produces a racemic mixture of D-glycero- alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7- phosphate. |
| SIMILARITY | Belongs to the SIS family. GmhA subfamily. |
Keywords
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Gene Ontology
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| GO:0008270; Molecular function:zinc ion binding |
| GO:0008968; Molecular function:D-sedoheptulose 7-phosphate isomerase activity |
| GO:0005975; Biological process:carbohydrate metabolic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: GMHA_BURPS (Q93UJ2) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 55 | 57 | /ligand="substrate" | N-x-G | ||||||||
| BINDING | 97 | 98 | /ligand="substrate" | N-D | ||||||||
| BINDING | 123 | 125 | /ligand="substrate" | [ST]-T-S | ||||||||
| BINDING | 64 | 64 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | ||||||||
| BINDING | 68 | 68 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
[EQN] | ||||||||
| BINDING | 175 | 175 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
[QH] | ||||||||
| BINDING | 183 | 183 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | ||||||||
| BINDING | 68 | 68 | /ligand="substrate" | [EQN] | ||||||||
| BINDING | 128 | 128 | /ligand="substrate" | S | ||||||||
| BINDING | 175 | 175 | /ligand="substrate" | [QH] | ||||||||
Additional information
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| Size range | 182-231 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |