HAMAP rule MF_00069
General rule information
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Accession | MF_00069 |
Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 42) |
Name | Hydroxylam_reduct |
Scope(s) |
Bacteria Archaea |
Template(s) | P31101 (HCP_DESVH); Q01770 (HCP_DESDA); P75825 (HCP_ECOLI); Q6WRT6 (HCP_RHOCA); [ Recover all ] |
Triggered by |
HAMAP; MF_00069 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | HCP |
Protein name | RecName: Full=Hydroxylamine reductase; EC=1.7.99.1; AltName: Full=Hybrid-cluster protein; Short=HCP; AltName: Full=Prismane protein; |
Gene name | Name=hcp; |
Comments
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FUNCTION | Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. |
CATALYTIC ACTIVITY | Reaction=A + H2O + NH4(+) = AH2 + H(+) + hydroxylamine; Xref=Rhea:RHEA:22052, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15429, ChEBI:CHEBI:17499, ChEBI:CHEBI:28938; EC=1.7.99.1; |
case <OC:Gammaproteobacteria> and <FTGroup:1> | |
COFACTOR | Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Note=Binds 1 [2Fe-2S] cluster.; |
end case | |
case not <OC:Gammaproteobacteria> and <FTGroup:2> | |
COFACTOR | Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster.; |
end case | |
case <FTGroup:3> | |
COFACTOR | Name=hybrid [4Fe-2O-2S] cluster; Xref=ChEBI:CHEBI:60519; Note=Binds 1 hybrid [4Fe-2O-2S] cluster.; |
end case | |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the HCP family. |
Keywords
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Cytoplasm | |
Oxidoreductase | |
case <FTGroup:1> or <FTGroup:2> or <FTGroup:3> | |
Metal-binding | |
Iron | |
Iron-sulfur | |
end case | |
case <OC:Gammaproteobacteria> and <FTGroup:1> | |
2Fe-2S | |
end case | |
case not <OC:Gammaproteobacteria> and <FTGroup:2> | |
4Fe-4S | |
end case |
Gene Ontology
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GO:0005737; Cellular component:cytoplasm |
GO:0050418; Molecular function:hydroxylamine reductase activity |
GO:0051536; Molecular function:iron-sulfur cluster binding |
Cross-references
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Features
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From: HCP_ECOLI (P75825) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
case <OC:Gammaproteobacteria> | ||||||||||||
BINDING | 3 | 3 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135" |
C | 1 | |||||||
BINDING | 6 | 6 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135" |
C | 1 | |||||||
BINDING | 18 | 18 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135" |
C | 1 | |||||||
BINDING | 25 | 25 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135" |
C | 1 | |||||||
end case | ||||||||||||
From: HCP_DESVH (P31101) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
case not <OC:Gammaproteobacteria> | ||||||||||||
BINDING | 3 | 3 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | 2 | |||||||
BINDING | 6 | 6 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | 2 | |||||||
BINDING | 15 | 15 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | 2 | |||||||
BINDING | 21 | 21 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | 2 | |||||||
end case | ||||||||||||
BINDING | 244 | 244 | /ligand="hybrid [4Fe-2O-2S] cluster" /ligand_id="ChEBI:CHEBI:60519" |
H | 3 | |||||||
BINDING | 268 | 268 | /ligand="hybrid [4Fe-2O-2S] cluster" /ligand_id="ChEBI:CHEBI:60519" |
E | 3 | |||||||
BINDING | 312 | 312 | /ligand="hybrid [4Fe-2O-2S] cluster" /ligand_id="ChEBI:CHEBI:60519" |
C | 3 | |||||||
BINDING | 406 | 406 | /ligand="hybrid [4Fe-2O-2S] cluster" /ligand_id="ChEBI:CHEBI:60519" /note="via persulfide group" |
C | 3 | |||||||
BINDING | 434 | 434 | /ligand="hybrid [4Fe-2O-2S] cluster" /ligand_id="ChEBI:CHEBI:60519" |
C | 3 | |||||||
BINDING | 459 | 459 | /ligand="hybrid [4Fe-2O-2S] cluster" /ligand_id="ChEBI:CHEBI:60519" |
C | 3 | |||||||
BINDING | 494 | 494 | /ligand="hybrid [4Fe-2O-2S] cluster" /ligand_id="ChEBI:CHEBI:60519" |
E | 3 | |||||||
BINDING | 496 | 496 | /ligand="hybrid [4Fe-2O-2S] cluster" /ligand_id="ChEBI:CHEBI:60519" |
K | 3 | |||||||
MOD_RES | 406 | 406 | /note="Cysteine persulfide" | C |
Additional information
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Size range | 427-570 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | Possible wrong start in THEMA and ACIFR. Deleted domain in THEMA/METTH. |