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HAMAP rule MF_00069

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General rule information [?]

Accession MF_00069
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 42)
Name Hydroxylam_reduct
Scope(s) Bacteria
Archaea
Template(s) P31101 (HCP_DESVH); Q01770 (HCP_DESDA); P75825 (HCP_ECOLI); Q6WRT6 (HCP_RHOCA); [ Recover all ]
Triggered by HAMAP; MF_00069 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HCP
Protein name RecName: Full=Hydroxylamine reductase;
                 EC=1.7.99.1;
AltName: Full=Hybrid-cluster protein;
                 Short=HCP;
AltName: Full=Prismane protein;
Gene name Name=hcp;

Comments [?]

FUNCTIONCatalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
CATALYTIC ACTIVITY Reaction=A + H2O + NH4(+) = AH2 + H(+) + hydroxylamine; Xref=Rhea:RHEA:22052, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15429, ChEBI:CHEBI:17499, ChEBI:CHEBI:28938; EC=1.7.99.1;
case <OC:Gammaproteobacteria> and <FTGroup:1>
COFACTOR Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Note=Binds 1 [2Fe-2S] cluster.;
end case
case not <OC:Gammaproteobacteria> and <FTGroup:2>
COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster.;
end case
case <FTGroup:3>
COFACTOR Name=hybrid [4Fe-2O-2S] cluster; Xref=ChEBI:CHEBI:60519; Note=Binds 1 hybrid [4Fe-2O-2S] cluster.;
end case
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the HCP family.

Keywords [?]

Cytoplasm
Oxidoreductase
case <FTGroup:1> or <FTGroup:2> or <FTGroup:3>
Metal-binding
Iron
Iron-sulfur
end case
case <OC:Gammaproteobacteria> and <FTGroup:1>
2Fe-2S
end case
case not <OC:Gammaproteobacteria> and <FTGroup:2>
4Fe-4S
end case

Gene Ontology [?]

GO:0005737; Cellular component:cytoplasm
GO:0050418; Molecular function:hydroxylamine reductase activity
GO:0051536; Molecular function:iron-sulfur cluster binding

Cross-references [?]

Pfam PF03063; Prismane; 1;
NCBIfam TIGR01703; hybrid_clust; 1;

Features [?]

From: HCP_ECOLI (P75825)
Key From To Description Tag Condition FTGroup
case <OC:Gammaproteobacteria>
BINDING 3 3 /ligand="[2Fe-2S] cluster"
/ligand_id="ChEBI:CHEBI:190135"
C 1
BINDING 6 6 /ligand="[2Fe-2S] cluster"
/ligand_id="ChEBI:CHEBI:190135"
C 1
BINDING 18 18 /ligand="[2Fe-2S] cluster"
/ligand_id="ChEBI:CHEBI:190135"
C 1
BINDING 25 25 /ligand="[2Fe-2S] cluster"
/ligand_id="ChEBI:CHEBI:190135"
C 1
end case
From: HCP_DESVH (P31101)
Key From To Description Tag Condition FTGroup
case not <OC:Gammaproteobacteria>
BINDING 3 3 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
C 2
BINDING 6 6 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
C 2
BINDING 15 15 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
C 2
BINDING 21 21 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
C 2
end case
BINDING 244 244 /ligand="hybrid [4Fe-2O-2S] cluster"
/ligand_id="ChEBI:CHEBI:60519"
H 3
BINDING 268 268 /ligand="hybrid [4Fe-2O-2S] cluster"
/ligand_id="ChEBI:CHEBI:60519"
E 3
BINDING 312 312 /ligand="hybrid [4Fe-2O-2S] cluster"
/ligand_id="ChEBI:CHEBI:60519"
C 3
BINDING 406 406 /ligand="hybrid [4Fe-2O-2S] cluster"
/ligand_id="ChEBI:CHEBI:60519"
/note="via persulfide group"
C 3
BINDING 434 434 /ligand="hybrid [4Fe-2O-2S] cluster"
/ligand_id="ChEBI:CHEBI:60519"
C 3
BINDING 459 459 /ligand="hybrid [4Fe-2O-2S] cluster"
/ligand_id="ChEBI:CHEBI:60519"
C 3
BINDING 494 494 /ligand="hybrid [4Fe-2O-2S] cluster"
/ligand_id="ChEBI:CHEBI:60519"
E 3
BINDING 496 496 /ligand="hybrid [4Fe-2O-2S] cluster"
/ligand_id="ChEBI:CHEBI:60519"
K 3
MOD_RES 406 406 /note="Cysteine persulfide" C

Additional information [?]

Size range 427-570 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Possible wrong start in THEMA and ACIFR. Deleted domain in THEMA/METTH.



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