HAMAP

Accession	MF_00072
Dates	1-JUN-2001 (Created) 9-DEC-2011 (Last updated, Version 27)

Data class

Protein

Predictors

HAMAP; MF_00072; [distribution of match scores in UniProtKB];[seed alignment for MF_00072]

Names

Rel_fac_3

Identifier

RF3

Protein name

RecName: Full=Peptide chain release factor 3; Short=RF-3;

Gene name

prfC

FUNCTION: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the GTP-binding elongation factor family. PrfC subfamily.

Pfam	PF00009; GTP_EFTU; 1; PF03144; GTP_EFTU_D2; 1;
TIGRFAMs	TIGR00503; PrfC; 1;
PROSITE	PS00301; EFACTOR_GTP; 1;

Cytoplasm, Protein biosynthesis, GTP-binding, Nucleotide-binding.

GO:0005525; Molecular function: GTP binding.
GO:0016149; Molecular function: translation release factor activity, codon specific.
GO:0006449; Biological process: regulation of translational termination.
GO:0005737; Cellular component: cytoplasm.

From: RF3_ECOLI (P0A7I4)
Key		From		To		Description		Condition		FTGroup
NP_BIND		20		27		GTP (By similarity)		S-H-P-D-A-G-K-T
NP_BIND		88		92		GTP (By similarity)		D-T-P-G-H
NP_BIND		142		145		GTP (By similarity)		N-K-[LMYCVF]-D

Size range:	510-556 amino acids
Related UniRules:	None
Template:	P0A7I4 (RF3_ECOLI)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	in RALSO