HAMAP rule MF_00075
General rule information
[?]
| Accession | MF_00075 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 44) |
| Name | IF_1 |
| Scope(s) |
Bacteria Plastid |
| Template(s) | P69222 (IF1_ECOLI); Q5SHR1 (IF1_THET8); [ Recover all ] |
| Triggered by |
HAMAP; MF_00075 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| case not <OG:Chloroplast> | |
| Identifier | IF1 |
| Protein name | RecName: Full=Translation initiation factor IF-1; |
| end case | |
| case <OG:Chloroplast> | |
| Identifier | IF1C |
| Protein name | RecName: Full=Translation initiation factor IF-1, chloroplastic; |
| end case | |
| Gene name | Name=infA; |
Comments
[?]
| FUNCTION | One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. |
| SUBUNIT | Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly. |
| case not <OG:Chloroplast> | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| end case | |
| case <OG:Chloroplast> | |
| SUBCELLULAR LOCATION | Plastid, chloroplast. |
| end case | |
| SIMILARITY | Belongs to the IF-1 family. |
Keywords
[?]
| case not <OG:Chloroplast> | |
| Cytoplasm | |
| end case | |
| Initiation factor | |
| Protein biosynthesis | |
| RNA-binding | |
| rRNA-binding | |
| case <OC:Bacillaceae> and <FT:1> | |
| Phosphoprotein | |
| end case | |
Gene Ontology
[?]
| GO:0019843; Molecular function:rRNA binding | |
| GO:0003743; Molecular function:translation initiation factor activity | |
| GO:0006413; Biological process:translational initiation | |
| GO:0043022; Molecular function:ribosome binding | |
| case not <OG:Chloroplast> | |
| GO:0005737; Cellular component:cytoplasm | |
| end case | |
| case <OG:Chloroplast> | |
| GO:0009507; Cellular component:chloroplast | |
| end case | |
Cross-references
[?]
Features
[?]
| From: IF1_BACSU (P20458) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Bacillaceae> | ||||||||||||
| MOD_RES | 60 | 60 | /note="Phosphotyrosine" | Y | ||||||||
| end case | ||||||||||||
Additional information
[?]
| Size range | 70-113 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Possible wrong start in MYCSP Pseudogene in the plastid genome in most rosids (including ARATH), and Solanaceae (including TOBAC). MEDLINE=21149877; PubMed=11251102; DOI=10.1105/tpc.13.3.645; Millen R.S., Olmstead R.G., Adams K.L., Palmer J.D., Lao N.T., Heggie L., Kavanagh T.A., Hibberd J.M., Gray J.C., Morden C.W., Calie P.J., Jermiin L.S., Wolfe K.H.; "Many parallel losses of infA from chloroplast DNA during angiosperm evolution with multiple independent transfers to the nucleus."; Plant Cell 13:645-658(2001). |