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HAMAP rule MF_00076

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General rule information [?]

Accession MF_00076
Dates 14-JUN-2002 (Created)
28-JUN-2024 (Last updated, Version 34)
Name HisB
Scope(s) Bacteria
Archaea
Template(s) Q02134 (HIS7_LACLA); [ Recover all ]
Triggered by HAMAP; MF_00076 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HIS7
Protein name RecName: Full=Imidazoleglycerol-phosphate dehydratase;
                 Short=IGPD;
                 EC=4.2.1.19;
Gene name Name=hisB;

Comments [?]

CATALYTIC ACTIVITY Reaction=D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol- 4-yl)-2-oxopropyl phosphate + H2O; Xref=Rhea:RHEA:11040, ChEBI:CHEBI:15377, ChEBI:CHEBI:57766, ChEBI:CHEBI:58278; EC=4.2.1.19;
PATHWAYAmino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the imidazoleglycerol-phosphate dehydratase family.

Keywords [?]


Gene Ontology [?]

GO:0004424; Molecular function:imidazoleglycerol-phosphate dehydratase activity
GO:0000105; Biological process:L-histidine biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00475; IGPD; 1;
PROSITE PS00954; IGP_DEHYDRATASE_1; 1;
PROSITE PS00955; IGP_DEHYDRATASE_2; 1;

Features [?]


Additional information [?]

Size range 176-216 amino acids
Related rules MF_01022
Fusion Nter: None Cter: None
Comments Longer N-terminal in NEIMA and NEIMB; not shown in alignment and not taken into account in size range. See MF_01022 for bifunctional hisB.



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