HAMAP

Accession	MF_00077
Dates	1-JUN-2001 (Created) 19-JUL-2011 (Last updated, Version 23)

Data class

Protein

Predictors

HAMAP; MF_00077; [distribution of match scores in UniProtKB];[seed alignment for MF_00077]

Names

tRNA_methyltr_aTrm56

Identifier

TRM56

Protein name

RecName: Full=tRNA (cytidine(56)-2'-O)-methyltransferase; EC=2.1.1.206; AltName: Full=tRNA ribose 2'-O-methyltransferase aTrm56;

FUNCTION: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs (By similarity).

CATALYTIC ACTIVITY: S-adenosyl-L-methionine + cytidine(56) in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine(56) in tRNA.

SUBUNIT: Homodimer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (Potential).

SIMILARITY: Belongs to the aTrm56 family.

Pfam	PF01994; Trm56; 1; PF01966; HD; 0-1; trigger=Yes;
TIGRFAMs	TIGR00277; HDIG; 0-1;

Cytoplasm, Methyltransferase, S-adenosyl-L-methionine, Transferase, tRNA processing.

GO:0008175; Molecular function: tRNA methyltransferase activity.
GO:0002128; Biological process: tRNA nucleoside ribose methylation.
GO:0005737; Cellular component: cytoplasm.

From: TRM56_PYRHO (O58214)
Key		From		To		Description		Condition		FTGroup
REGION (Optional)		109		113		S-adenosyl-L-methionine binding (By similarity)		G-[GAS]-[ED]-[KR]-V
REGION (Optional)		127		134		S-adenosyl-L-methionine binding (By similarity)		[VI]-[GAS]-N-Q-P-H-S-E
BINDING		80		80		S-adenosyl-L-methionine; via carbonyl oxygen (By similarity)		L

Size range:	168-218 amino acids
Related UniRules:	None
Template:	O58214 (TRM56_PYRHO); Q9UYD1 (TRM56_PYRAB); O29507 (TRM56_ARCFU): [Recover all]
Scope:	Archaea
Fusion:	Nter: None; Cter: <HD domain>
Duplicate:	None
Plasmid encoded:	None
Comments:	Shorter N-terminus in SULAC and SULSO.