HAMAP rule MF_00079

General rule information [?]

Accession	MF_00079
Dates	1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 43)
Name	HisG_Long
Scope(s)	Bacteria Archaea
Template(s)	P60757 (HIS1_ECOLI); P00499 (HIS1_SALTY); P9WMN1 (HIS1_MYCTU); [ Recover all ]
Triggered by	HAMAP; MF_00079 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	HIS1
Protein name	RecName: Full=ATP phosphoribosyltransferase; Short=ATP-PRT; Short=ATP-PRTase; EC=2.4.2.17;
Gene name	Name=hisG;

Comments [?]

FUNCTION	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
CATALYTIC ACTIVITY	Reaction=1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho- alpha-D-ribose 1-diphosphate + ATP; Xref=Rhea:RHEA:18473, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017, ChEBI:CHEBI:73183; EC=2.4.2.17;
COFACTOR	Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
ACTIVITY REGULATION	Feedback inhibited by histidine.
PATHWAY	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
case <OC:Enterobacterales> or <OC:Mycobacteriaceae>
SUBUNIT	Equilibrium between an active dimeric form, an inactive hexameric form and higher aggregates. Interconversion between the various forms is largely reversible and is influenced by the natural substrates and inhibitors of the enzyme.
end case
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the ATP phosphoribosyltransferase family. Long subfamily.

Keywords [?]

Gene Ontology [?]

GO:0003879; Molecular function:ATP phosphoribosyltransferase activity

GO:0000287; Molecular function:magnesium ion binding

GO:0000105; Biological process:histidine biosynthetic process

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

Additional information [?]

Size range	281-325 amino acids
Related rules	MF_01018
Fusion	Nter: None Cter: None
Comments	Possible wrong start in HAEIN. Possible wrong start in ARCFU; not shown in alignment and not taken into account in size range. See MF_01018 for the entry relevant to the "short" hisG.