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HAMAP annotation rule: MF_00082
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General rule information

Accession MF_00082
Dates 1-JUN-2001 (Created)
12-MAY-2011 (Last updated, Version 48)
Data class Protein

case <OC:Bacteria> or <OG:Chloroplast>
Predictors HAMAP; MF_00082_B; [distribution of match scores in UniProtKB];[seed alignment for MF_00082_B]
end case


case <OC:Archaea>
Predictors HAMAP; MF_00082_A; [distribution of match scores in UniProtKB];[seed alignment for MF_00082_A]
end case

Names ArgB


Propagated annotation

Identifier, protein and gene names
Identifier ARGB

case not <OC:Deinococci> and not <OC:Pyrococcus> and not <OC:Crenarchaeota>
Protein name
RecName: Full=Acetylglutamate kinase;
EC=2.7.2.8;
AltName: Full=N-acetyl-L-glutamate 5-phosphotransferase;
AltName: Full=NAG kinase;
Short=AGK;
Gene name argB
end case


case <OC:Deinococci> or <OC:Pyrococcus> or <OC:Crenarchaeota>
Protein name
RecName: Full=Acetylglutamate/acetylaminoadipate kinase;
EC=2.7.2.-;
EC=2.7.2.8;
AltName: Full=N-acetyl-L-glutamate/N-acetyl-L-aminoadipate 5-phosphotransferase;
AltName: Full=NAG kinase;
Short=AGK;
Gene name argB, lysZ
end case

Comments

case <OC:Deinococci> or <OC:Pyrococcus> or <OC:Crenarchaeota>
FUNCTION: Involved in both the arginine and lysine biosynthetic pathways (By similarity).
end case

CATALYTIC ACTIVITY: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate.

case <OC:Deinococci> or <OC:Pyrococcus> or <OC:Crenarchaeota>
CATALYTIC ACTIVITY: ATP + N-acetyl-L-aminoadipate = ADP + N-acetyl-L-aminoadipate 5-phosphate.
end case

PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.

case <OC:Deinococci> or <OC:Pyrococcus> or <OC:Crenarchaeota>
PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5.
end case


case <OC:Enterobacteriaceae>
SUBUNIT: Homodimer (By similarity).
end case


case <OC:Mycobacterium> or <OC:Pseudomonas> or <OC:Thermotoga>
SUBUNIT: Homohexamer (By similarity).
end case


case <OG:Chloroplast>
SUBCELLULAR LOCATION: Plastid, chloroplast.
end case


case not <OG:Chloroplast>
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
end case

SIMILARITY: Belongs to the acetylglutamate kinase family.
Cross-references
Pfam PF00696; AA_kinase; 1;
PIRSF PIRSF000728; NAGK; 1;
TIGRFAMs TIGR00761; ArgB; 1;
Keywords

case not <OG:Chloroplast>
Cytoplasm.
end case

Amino-acid biosynthesis, Arginine biosynthesis, ATP-binding.

case <OC:Deinococci> or <OC:Pyrococcus> or <OC:Crenarchaeota>
Lysine biosynthesis.
end case

Nucleotide-binding, Transferase, Kinase.
Gene Ontology
GO:0003991; Molecular function: acetylglutamate kinase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006526; Biological process: arginine biosynthetic process.

case <OC:Deinococci> or <OC:Pyrococcus> or <OC:Crenarchaeota>
GO:0009085; Biological process: lysine biosynthetic process.
end case


case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case


case not <OG:Chloroplast>
GO:0005737; Cellular component: cytoplasm.
end case

Features

case <OC:Enterobacteriaceae>
From: ARGB_ECOLI (P0A6C8)
Key     From     To       Description   Condition   FTGroup
NP_BIND     181     186       ATP (By similarity)   D-[VI]-S-[GS]-I-L  
NP_BIND     209     211       ATP (By similarity)   I-I-T  
end case

case <OC:Bacteria>
Key     From     To       Description   Condition   FTGroup
REGION     44     45       Substrate binding (By similarity)   [GA]-[GSA]  
BINDING     66     66       Substrate (By similarity)   R  
BINDING     158     158       Substrate (By similarity)   N  
SITE     8     8       Transition state stabilizer (By similarity)   K  
SITE     217     217       Transition state stabilizer (By similarity)   K  
end case

case <OC:Archaea>
From: ARGB_SULSO (Q980X0)
Key     From     To       Description   Condition   FTGroup
REGION     35     36       Substrate binding (By similarity)   G-[GS]  
BINDING     62     62       Substrate (By similarity)   R  
BINDING     167     167       Substrate (By similarity)   N  
SITE     5     5       Transition state stabilizer (By similarity)   K  
SITE     224     224       Transition state stabilizer (By similarity)   K  
end case



Additional information

Size range: 244-362 amino acids
Related UniRules: None
Template: P0A6C8 (ARGB_ECOLI); Q9HTN2 (ARGB_PSEAE); Q9X2A4 (ARGB_THEMA); Q980X0 (ARGB_SULSO); P0A4Y6 (ARGB_MYCTU): [Recover all]
Scope: Bacteria
Archaea
Plastid
Fusion: Nter: None; Cter: <Unknown>
Duplicate: None
Plasmid encoded: None
Comments: There are divergent sequences in THETH and DEIRA which could be something else than argB

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UniProtKB rule member sequences