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HAMAP rule MF_00082
General rule information
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| Accession | MF_00082 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 60) |
| Name | ArgB |
| Scope(s) |
Bacteria Archaea Plastid |
| Template(s) | P0A6C8 (ARGB_ECOLI); Q9HTN2 (ARGB_PSEAE); Q9X2A4 (ARGB_THEMA); Q72HA9 (ARGB_THET2); P9WQ01 (ARGB_MYCTU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00082 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ARGB |
| Protein name | RecName: Full=Acetylglutamate kinase; EC=2.7.2.8; AltName: Full=N-acetyl-L-glutamate 5-phosphotransferase; AltName: Full=NAG kinase; Short=NAGK; |
| Gene name | Name=argB; |
Comments
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| FUNCTION | Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate. |
| CATALYTIC ACTIVITY | Reaction=ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5- phosphate; Xref=Rhea:RHEA:14629, ChEBI:CHEBI:30616, ChEBI:CHEBI:44337, ChEBI:CHEBI:57936, ChEBI:CHEBI:456216; EC=2.7.2.8; |
| PATHWAY | Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl- L-ornithine from L-glutamate: step 2/4. |
| case <OC:Enterobacterales> | |
| SUBUNIT | Homodimer. |
| end case | |
| case <OC:Bacteria> or <OC:Archaea> | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| else case <OG:Chloroplast> | |
| SUBCELLULAR LOCATION | Plastid, chloroplast. |
| end case | |
| SIMILARITY | Belongs to the acetylglutamate kinase family. ArgB subfamily. |
Keywords
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| Amino-acid biosynthesis | |
| Arginine biosynthesis | |
| ATP-binding | |
| case <OC:Bacteria> or <OC:Archaea> | |
| Cytoplasm | |
| end case | |
| Kinase | |
| Nucleotide-binding | |
| Transferase | |
Gene Ontology
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| GO:0003991; Molecular function:acetylglutamate kinase activity | |
| GO:0005524; Molecular function:ATP binding | |
| GO:0042450; Biological process:arginine biosynthetic process via ornithine | |
| case <OG:Chloroplast> | |
| GO:0009507; Cellular component:chloroplast | |
| end case | |
| case <OCellular component:Bacteria> or <OC:Archaea> | |
| GO:0005737; Cellular component:cytoplasm | |
| end case | |
Cross-references
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| Pfam | PF00696; AA_kinase; 1; |
| PRINTS | PR00474; GLU5KINASE; 1; |
| NCBIfam | TIGR00761; argB; 1; |
| PIRSF | PIRSF000728; NAGK; 1; |
Features
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| From: ARGB_ECOLI (P0A6C8) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Enterobacterales> | ||||||||||||
| BINDING | 181 | 186 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
D-[VI]-S-[GS]-I-L | ||||||||
| BINDING | 209 | 211 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
I-I-T | ||||||||
| end case | ||||||||||||
| BINDING | 44 | 45 | /ligand="substrate" | [GA]-[GSA] | ||||||||
| BINDING | 66 | 66 | /ligand="substrate" | R | ||||||||
| BINDING | 158 | 158 | /ligand="substrate" | N | ||||||||
| SITE | 8 | 8 | /note="Transition state stabilizer" | K | ||||||||
| SITE | 217 | 217 | /note="Transition state stabilizer" | K | ||||||||
Additional information
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| Size range | 220-390 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: <Unknown> |
| Comments | Signature does not match Xanthomonadaceae, which have a longer C-terminus. |